Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas

  • Authors:
    • Xia Zhang
    • Xiaoyan Wang
    • Xingguo Song
    • Zengtao Wei
    • Chengjun Zhou
    • Faliang Zhu
    • Qun Wang
    • Chunhong Ma
    • Liling Zhang
  • View Affiliations

  • Published online on: December 13, 2010     https://doi.org/10.3892/or.2010.1103
  • Pages: 353-358
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Abstract

Programmed cell death 5 (PDCD5) is a novel apoptosis-promoting protein. Although the decreased expression of PDCD5 has been recently found in a few types of human tumors, the status and significance of PDCD5 in ovarian cancer has not been evaluated. In the present study, we detected PDCD5 expression in 20 normal human ovaries and 26 serous cystadenomas and 41 serous cystadenocarcinomas by RT-PCR, Western blotting and immunohistochemistry, and analyzed the relationship between PDCD5 expression and clinicopathological data or patient survival. PDCD5 was expressed in all normal ovaries and serous cystadenomas, 80% (16/20) of normal ovarian tissues and 76.9% (20/26) of serous cystadenomas with moderate or strong PDCD5 protein expression. In contrast, 22% (9/41) of serous cystadenocarcinomas had no detectable PDCD5 protein expression and 46.3% (19/41) exhibited weak PDCD5 expression. The overall expression of PDCD5 in serous cystadenocarcinoma was significantly lower compared with normal ovarian tissues or serous cystadenomas (p<0.01). Furthermore, lost or decreased PDCD5 expression in serous cystadenocarcinomas was associated significantly with FIGO stage (p<0.05) and poorer disease-specific survival of patients (p<0.05). In conclusion, our data suggest that lost or reduced PDCD5 expression may contribute to the pathogenesis of human serous cystadenocarcinomas.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang X, Wang X, Song X, Wei Z, Zhou C, Zhu F, Wang Q, Ma C and Zhang L: Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncol Rep 25: 353-358, 2011
APA
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F. ... Zhang, L. (2011). Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas. Oncology Reports, 25, 353-358. https://doi.org/10.3892/or.2010.1103
MLA
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F., Wang, Q., Ma, C., Zhang, L."Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas". Oncology Reports 25.2 (2011): 353-358.
Chicago
Zhang, X., Wang, X., Song, X., Wei, Z., Zhou, C., Zhu, F., Wang, Q., Ma, C., Zhang, L."Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas". Oncology Reports 25, no. 2 (2011): 353-358. https://doi.org/10.3892/or.2010.1103