Sox4 stimulates ß-catenin activity through induction of CK2

  • Authors:
    • Ae-Kyung Lee
    • Sang-Gun Ahn
    • Jung-Hoon Yoon
    • Soo-A Kim
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  • Published online on: December 9, 2010     https://doi.org/10.3892/or.2010.1091
  • Pages: 559-565
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Abstract

ß-catenin is a key component of the Wnt signaling pathway and the abnormal accumulation of ß-catenin is characteristic of various types of cancer. Here we demonstrate that overexpression of Sox4 enhances ß-catenin/TCF activity by increasing the stability of ß-catenin. Sox4 increased the protein level of ß-catenin and its target gene cyclin D1 in a dose-dependent manner. An siRNA experiment for Sox4 also demonstrated that Sox4 increases the protein levels of ß-catenin and thus activates the Wnt signaling pathway. We found that induction of ß-catenin/TCF activity by Sox4 is caused by stabilization of the ß-catenin protein, but not by induction of ß-catenin transcription. We further demonstrate that the increased level of ß-catenin is caused by induction of CK2. In light of recent evidence that Sox4 expression is activated in the colon and in other tumors with ß-catenin dysregulation, our findings suggest that Sox4 acts as an agonist of Wnt signaling in cancer cells.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lee A, Ahn S, Yoon J and Kim S: Sox4 stimulates ß-catenin activity through induction of CK2. Oncol Rep 25: 559-565, 2011
APA
Lee, A., Ahn, S., Yoon, J., & Kim, S. (2011). Sox4 stimulates ß-catenin activity through induction of CK2. Oncology Reports, 25, 559-565. https://doi.org/10.3892/or.2010.1091
MLA
Lee, A., Ahn, S., Yoon, J., Kim, S."Sox4 stimulates ß-catenin activity through induction of CK2". Oncology Reports 25.2 (2011): 559-565.
Chicago
Lee, A., Ahn, S., Yoon, J., Kim, S."Sox4 stimulates ß-catenin activity through induction of CK2". Oncology Reports 25, no. 2 (2011): 559-565. https://doi.org/10.3892/or.2010.1091