Open Access

Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue

  • Authors:
    • Miguel Torres-Martin
    • Luis Lassaletta
    • Alberto Isla
    • Jose M. De Campos
    • Giovanny R. Pinto
    • Rommel R. Burbano
    • Javier S. Castresana
    • Barbara Melendez
    • Juan A. Rey
  • View Affiliations

  • Published online on: October 3, 2014     https://doi.org/10.3892/or.2014.3526
  • Pages: 2327-2334
  • Copyright: © Torres-Martin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Schwannomas and grade I meningiomas are non‑metastatic neoplasms that share the common mutation of gene NF2. They usually appear in neurofibromatosis type 2 patients. Currently, there is no drug treatment available for both tumors, thus the use of wide expression technologies is crucial to identify therapeutic targets. Affymetrix Human Gene 1.0 ST was used to test global gene expression in 22 meningiomas, 31 schwannomas and, as non-tumoral controls, 3 healthy meningeal tissues, 8 non-tumoral nerves and 1 primary Schwann cell culture. A non-stringent P-value cut-off and fold change were used to establish deregulated genes. We identified a subset of genes that were upregulated in meningiomas and schwannomas when compared to their respectively healthy tissues, including PDGFD, CDH1 and SLIT2. Thus, these genes should be thoroughly studied as targets in a possible combined treatment.
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December-2014
Volume 32 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Torres-Martin M, Lassaletta L, Isla A, De Campos JM, Pinto GR, Burbano RR, Castresana JS, Melendez B and Rey JA: Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncol Rep 32: 2327-2334, 2014
APA
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J.M., Pinto, G.R., Burbano, R.R. ... Rey, J.A. (2014). Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncology Reports, 32, 2327-2334. https://doi.org/10.3892/or.2014.3526
MLA
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J. M., Pinto, G. R., Burbano, R. R., Castresana, J. S., Melendez, B., Rey, J. A."Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue". Oncology Reports 32.6 (2014): 2327-2334.
Chicago
Torres-Martin, M., Lassaletta, L., Isla, A., De Campos, J. M., Pinto, G. R., Burbano, R. R., Castresana, J. S., Melendez, B., Rey, J. A."Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue". Oncology Reports 32, no. 6 (2014): 2327-2334. https://doi.org/10.3892/or.2014.3526