CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer

  • Authors:
    • Shan Liao
    • Songshu Xiao
    • Guangchao Zhu
    • Danwei Zheng
    • Junyu He
    • Zhen Pei
    • Guiyuan Li
    • Yanhong Zhou
  • View Affiliations

  • Published online on: October 10, 2014     https://doi.org/10.3892/or.2014.3537
  • Pages: 2703-2709
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Abstract

Cervical cancer is the second most common cancer and the fifth most deadly malignancy in females worldwide, affecting 500,000 individuals each year. It is the leading cause of cancer mortality among women in developing countries. Dysregulated activation of genes, such as CD44, SOX9 and SKP2, plays a role in cervical cancer. CD38 is known to be involved in activities typical of cell surface receptors, such as signaling for activation and proliferation events and heterotypic cell adhesion. CD38 contributes to disease progression and relapse in certain tumors, such as acute myeloid and chronic lymphocytic leukemia. To the best of our knowledge, there is currently no report on the relationship between CD38 and cervical cancer. Using qPCR, immunohistochemistry, and western blot analysis, the expression levels of CD38 were investigated and found to be upregulated in cervical cancer. CD38 was correlated with dysregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in cervical cancer tissues in vitro. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo. The results of the present study suggested that CD38 is highly expressed in cervical carcinoma tissues and play an important role in dysregulation of the PI3K/Akt signaling pathway.
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December-2014
Volume 32 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liao S, Xiao S, Zhu G, Zheng D, He J, Pei Z, Li G and Zhou Y: CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. Oncol Rep 32: 2703-2709, 2014
APA
Liao, S., Xiao, S., Zhu, G., Zheng, D., He, J., Pei, Z. ... Zhou, Y. (2014). CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer. Oncology Reports, 32, 2703-2709. https://doi.org/10.3892/or.2014.3537
MLA
Liao, S., Xiao, S., Zhu, G., Zheng, D., He, J., Pei, Z., Li, G., Zhou, Y."CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer". Oncology Reports 32.6 (2014): 2703-2709.
Chicago
Liao, S., Xiao, S., Zhu, G., Zheng, D., He, J., Pei, Z., Li, G., Zhou, Y."CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer". Oncology Reports 32, no. 6 (2014): 2703-2709. https://doi.org/10.3892/or.2014.3537