Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors

  • Authors:
    • Shoki Sato
    • Takahiro Tsuchikawa
    • Toru Nakamura
    • Nagato  Sato
    • Eiji  Tamoto
    • Keisuke Okamura
    • Toshiaki  Shichinohe
    • Satoshi Hirano
  • View Affiliations

  • Published online on: October 6, 2014     https://doi.org/10.3892/or.2014.3530
  • Pages: 2753-2759
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Abstract

The disease frequency of pancreatic neuroendocrine tumors (PNETs) has been growing, and postoperative hepatic recurrence (PHR) is one of the factors affecting patient prognosis. The present study aimed to investigate biomarkers of PNETs in the primary disease site to predict PHR using immunohistochemical analysis for tumor-infiltrating lymphocytes (TILs: CD3, CD8 and CD45RO), human leukocyte antigen (HLA) class I, α-thalassemia/mental retardation X-linked (ATRX), death domain-associated protein (DAXX), mammalian target of rapamycin (mTOR) and phospho-mTOR (p-mTOR). Correlations were analyzed between TILs and the biomarkers, clinicopathological features and prognosis. Sixteen patients with PNETs who underwent radical surgery at our hospital were reviewed. We analyzed the correlation between PHR and immunohistochemical characteristics, and also between disease-free survival (DFS) or overall survival (OS) and the immunohistochemical characteristics. We found that PHR was associated with the expression patterns of DAXX and p-mTOR. No association was found between PHR and patient background, TILs or other biomarkers. DFS was found to be associated with ATRX, DAXX and p-mTOR. OS was associated only with p-mTOR. In conclusion, ATRX, DAXX and p-mTOR are useful molecular biomarkers for predicting PHR in patients who undergo radical surgery for PNETs. Use of these biomarkers will enable earlier decisions on which patients may benefit from adjuvant therapy.
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December-2014
Volume 32 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sato S, Tsuchikawa T, Nakamura T, Sato N, Tamoto E, Okamura K, Shichinohe T and Hirano S: Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors. Oncol Rep 32: 2753-2759, 2014
APA
Sato, S., Tsuchikawa, T., Nakamura, T., Sato, N., Tamoto, E., Okamura, K. ... Hirano, S. (2014). Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors. Oncology Reports, 32, 2753-2759. https://doi.org/10.3892/or.2014.3530
MLA
Sato, S., Tsuchikawa, T., Nakamura, T., Sato, N., Tamoto, E., Okamura, K., Shichinohe, T., Hirano, S."Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors". Oncology Reports 32.6 (2014): 2753-2759.
Chicago
Sato, S., Tsuchikawa, T., Nakamura, T., Sato, N., Tamoto, E., Okamura, K., Shichinohe, T., Hirano, S."Impact of the tumor microenvironment in predicting postoperative hepatic recurrence of pancreatic neuroendocrine tumors". Oncology Reports 32, no. 6 (2014): 2753-2759. https://doi.org/10.3892/or.2014.3530