Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1

  • Authors:
    • Mei Ji
    • Huirong Shi
    • Ya Xie
    • Zhao Zhao
    • Shunshuang Li
    • Cheng Chang
    • Xinghan Cheng
    • Yue Li
  • View Affiliations

  • Published online on: November 3, 2014     https://doi.org/10.3892/or.2014.3580
  • Pages: 133-140
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Abstract

Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC specimens and EOC cell lines with important functional consequences. A high level of USP22 in EOC tissues was associated with advanced clinical FIGO stage, lymph node metastasis and worse prognosis. Patients with higher USP22 expression had shorter relapse-free and overall survival. Depletion of USP22 suppressed cell proliferation in vitro and tumor growth in vivo. We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-β1 (TGFB1). Our results indicate that USP22 functions as an oncogene in EOC, and thus USP22 may serve as a potential therapeutic target for individualized EOC treatment.
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January-2015
Volume 33 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ji M, Shi H, Xie Y, Zhao Z, Li S, Chang C, Cheng X and Li Y: Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1. Oncol Rep 33: 133-140, 2015
APA
Ji, M., Shi, H., Xie, Y., Zhao, Z., Li, S., Chang, C. ... Li, Y. (2015). Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1. Oncology Reports, 33, 133-140. https://doi.org/10.3892/or.2014.3580
MLA
Ji, M., Shi, H., Xie, Y., Zhao, Z., Li, S., Chang, C., Cheng, X., Li, Y."Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1". Oncology Reports 33.1 (2015): 133-140.
Chicago
Ji, M., Shi, H., Xie, Y., Zhao, Z., Li, S., Chang, C., Cheng, X., Li, Y."Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1". Oncology Reports 33, no. 1 (2015): 133-140. https://doi.org/10.3892/or.2014.3580