Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma

  • Authors:
    • Bin Yi
    • Yi Zhang
    • Dongming Zhu
    • Lifeng Zhang
    • Shiduo Song
    • Songbing He
    • Bing Zhang
    • Dechun Li
    • Jian Zhou
  • View Affiliations

  • Published online on: January 7, 2015     https://doi.org/10.3892/or.2015.3707
  • Pages: 1201-1206
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Abstract

Rho GDP dissociation inhibitor 2 (RhoGDI2) has been found to be a regulator of tumor metastasis. However, the expression of RhoGDI2 and its clinicopathological significance as well as the pathway of RhoGDI2 in tumor metastasis have yet to be investigated. To investigate the role of RhoGDI2 in the progression and prognosis of pancreatic carcinoma (PC), the expression of RhoGDI2 in human PC tissues was examined and compared with the clinicopathological characteristics and prognosis. Moreover, the relationship between RhoGDI2 and E-cadherin was examined. The results indicated that RhoGDI2 was overexpressed in PC tissues and associated with clinicopathological characteristics, including clinical stage and lymph node metastasis. Patients with a RhoGDI2‑negative expression had a significantly longer survival time than those with a RhoGDI2‑positive expression. Additionally, the expression of RhoGDI2 was negatively correlated with the expression of E-cadherin in PC tissues. Taken together, the findings suggest that RhoGDI2 is important in the progression and prognosis of PC, and may be used as a potential prognostic biomarker and a therapeutic target for PC.
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March-2015
Volume 33 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yi B, Zhang Y, Zhu D, Zhang L, Song S, He S, Zhang B, Li D and Zhou J: Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma. Oncol Rep 33: 1201-1206, 2015
APA
Yi, B., Zhang, Y., Zhu, D., Zhang, L., Song, S., He, S. ... Zhou, J. (2015). Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma. Oncology Reports, 33, 1201-1206. https://doi.org/10.3892/or.2015.3707
MLA
Yi, B., Zhang, Y., Zhu, D., Zhang, L., Song, S., He, S., Zhang, B., Li, D., Zhou, J."Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma". Oncology Reports 33.3 (2015): 1201-1206.
Chicago
Yi, B., Zhang, Y., Zhu, D., Zhang, L., Song, S., He, S., Zhang, B., Li, D., Zhou, J."Overexpression of RhoGDI2 correlates with the progression and prognosis of pancreatic carcinoma". Oncology Reports 33, no. 3 (2015): 1201-1206. https://doi.org/10.3892/or.2015.3707