Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer

  • Authors:
    • Jin‑Lai Wei
    • Zhong‑Xue Fu
    • Min Fang
    • Jin‑Bao Guo
    • Qing‑Ning Zhao
    • Wei‑Dong Lu
    • Qiu‑Yuan Zhou
  • View Affiliations

  • Published online on: December 30, 2014     https://doi.org/10.3892/or.2014.3701
  • Pages: 1349-1357
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Abstract

Sestrin 2 is a conserved antioxidant protein that is involved in p53‑dependent antioxidant defenses and protects cells against oxidative stresses. The present study was conducted to examine the expression of sestrin 2 in colorectal cancer (CRC) and investigate a possible relationship between sestrin 2 expression and prognosis in CRC. The expression of sestrin 2 in human CRC tissues and cell lines was evaluated by immunohistochemical or immunofluorescent staining and western blot analysis. The correlations between sestrin 2 expression in human CRC tissues and clinicopathological variables, including overall survival (OS) and disease‑free survival (DFS), were analyzed. Both human CRC tissues and cell lines showed a decreased expression of sestrin 2. Furthermore, a low expression of sestrin 2 was significantly correlated with advanced tumor stage, lymphatic invasion, lymph node metastasis, vascular invasion and liver metastasis. Survival analysis showed that patients with low sestrin 2 staining had a significantly worse DFS and OS. Additionally, early or advanced stage CRC patients with a low expression of sestrin 2 had a shorter survival. In univariate analysis, the patients with low sestrin 2 expression, advanced tumor stage, lymphatic invasion, lymphatic node metastasis, vascular invasion, liver metastasis and peritoneal metastasis had shorter OS and DFS. In multivariate analysis, only low sestrin 2 expression, advanced tumor stage, lymphatic node metastasis, vascular invasion and liver metastasis remained as independent prognostic factors of poor OS and DFS. The findings suggested that a decreased expression of sestrin 2 is associated with an unfavorable prognosis, which suggests that it is a novel and crucial predictor for CRC metastasis.
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March-2015
Volume 33 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wei JL, Fu ZX, Fang M, Guo JB, Zhao QN, Lu WD and Zhou QY: Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. Oncol Rep 33: 1349-1357, 2015
APA
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., & Zhou, Q. (2015). Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. Oncology Reports, 33, 1349-1357. https://doi.org/10.3892/or.2014.3701
MLA
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., Zhou, Q."Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer". Oncology Reports 33.3 (2015): 1349-1357.
Chicago
Wei, J., Fu, Z., Fang, M., Guo, J., Zhao, Q., Lu, W., Zhou, Q."Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer". Oncology Reports 33, no. 3 (2015): 1349-1357. https://doi.org/10.3892/or.2014.3701