Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma

  • Authors:
    • Heyun Zhang
    • Wenbin Li
    • Pinbo Huang
    • Lehang Lin
    • Hua Ye
    • Dechen Lin
    • H. Phillip Koeffler
    • Jie Wang
    • Dong Yin
  • View Affiliations

  • Published online on: January 8, 2015     https://doi.org/10.3892/or.2015.3709
  • Pages: 1481-1492
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Abstract

Studies have reported that the CCN family of proteins plays an important role in stimulating tumorigenesis. However, the relationship between the CCN protein family members and the features of hepatocellular carcinoma (HCC) remains unclear. The objective of this study was to determine the relationship between the expression levels of CCN protein family members and the features of HCC. Expression levels of the CCN family of proteins in 80-paired primary HCC samples and 11 normal liver samples were determined by a quantitative real-time PCR assay. Enhanced expression of nephroblastoma overexpressed protein (NOV) and decreased expression of Wnt-induced secreted protein 1 (WISP1), cysteine-rich protein 61 (CYR61) and connective tissue growth factor (CTGF) were found in HCC samples when compared to levels in matched non-cancerous tissues. No significant difference in WISP2 was found between matched-pair samples; only a few samples showed WISP3 expression. Furthermore, the expression levels of NOV, WISP1 and CYR61 were closely correlated with certain clinical features, including venous invasion, cellular differentiation, pTNM stage, disease-free survival and overall survival. Our results suggest that HCC progression may be enhanced by NOV and suppressed by WISP1 and CYR61. Our statistical analysis suggests that these proteins may be valuable in determining the prognosis of this deadly disease and directs attention to modulating the levels of these proteins as a potential mode of therapy.

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March-2015
Volume 33 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang H, Li W, Huang P, Lin L, Ye H, Lin D, Koeffler HP, Wang J and Yin D: Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma. Oncol Rep 33: 1481-1492, 2015
APA
Zhang, H., Li, W., Huang, P., Lin, L., Ye, H., Lin, D. ... Yin, D. (2015). Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma. Oncology Reports, 33, 1481-1492. https://doi.org/10.3892/or.2015.3709
MLA
Zhang, H., Li, W., Huang, P., Lin, L., Ye, H., Lin, D., Koeffler, H. P., Wang, J., Yin, D."Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma". Oncology Reports 33.3 (2015): 1481-1492.
Chicago
Zhang, H., Li, W., Huang, P., Lin, L., Ye, H., Lin, D., Koeffler, H. P., Wang, J., Yin, D."Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma". Oncology Reports 33, no. 3 (2015): 1481-1492. https://doi.org/10.3892/or.2015.3709