1
|
Louis DN, Ohgaki H, Wiestler OD, Cavenee
WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007
WHO classification of tumours of the central nervous system. Acta
Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI
|
2
|
Bleeker FE, Molenaar RJ and Leenstra S:
Recent advances in the molecular understanding of glioblastoma. J
Neurooncol. 108:11–27. 2012. View Article : Google Scholar : PubMed/NCBI
|
3
|
Becker KP and Yu J: Status quo -
standard-of-care medical and radiation therapy for glioblastoma.
Cancer J. 18:12–19. 2012. View Article : Google Scholar : PubMed/NCBI
|
4
|
Eke I, Storch K, Kastner I, Vehlow A,
Faethe C, Mueller-Klieser W, Taucher-Scholz G, Temme A, Schackert G
and Cordes N: Three-dimensional invasion of human glioblastoma
cells remains unchanged by X-ray and carbon ion irradiation in
vitro. Int J Radiat Oncol Biol Phys. 84:e515–e523. 2012. View Article : Google Scholar : PubMed/NCBI
|
5
|
Liu TJ, LaFortune T, Honda T, Ohmori O,
Hatakeyama S, Meyer T, Jackson D, de Groot J and Yung WK:
Inhibition of both focal adhesion kinase and insulin-like growth
factor-I receptor kinase suppresses glioma proliferation in vitro
and in vivo. Mol Cancer Ther. 6:1357–1367. 2007. View Article : Google Scholar : PubMed/NCBI
|
6
|
Rieken S, Habermehl D, Mohr A, Wuerth L,
Lindel K, Weber K, Debus J and Combs SE: Targeting ανβ3 and ανβ5
inhibits photon-induced hypermigration of malignant glioma cells.
Radiat Oncol. 6:1322011. View Article : Google Scholar
|
7
|
Shi Q, Hjelmeland AB, Keir ST, Song L,
Wickman S, Jackson D, Ohmori O, Bigner DD, Friedman HS and Rich JN:
A novel low-molecular weight inhibitor of focal adhesion kinase,
TAE226, inhibits glioma growth. Mol Carcinog. 46:488–496. 2007.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Yang M, Li Y, Chilukuri K, Brady OA,
Boulos MI, Kappes JC and Galileo DS: L1 stimulation of human glioma
cell motility correlates with FAK activation. J Neurooncol.
105:27–44. 2011. View Article : Google Scholar : PubMed/NCBI
|
9
|
Reardon DA, Nabors LB, Stupp R and
Mikkelsen T: Cilengitide: an integrin-targeting
arginine-glycine-aspartic acid peptide with promising activity for
glioblastoma multiforme. Expert Opin Investig Drugs. 17:1225–1235.
2008. View Article : Google Scholar : PubMed/NCBI
|
10
|
Nabors LB, Mikkelsen T, Hegi ME, Ye X,
Batchelor T, Lesser G, Peereboom D, Rosenfeld MR, Olsen J, Brem S,
Fisher JD and Grossman SA: A safety run-in and randomized phase 2
study of cilengitide combined with chemoradiation for newly
diagnosed glioblastoma (NABTT 0306). Cancer. 118:5601–5607. 2012.
View Article : Google Scholar : PubMed/NCBI
|
11
|
McLean GW, Carragher NO, Avizienyte E,
Evans J, Brunton VG and Frame MC: The role of focal-adhesion kinase
in cancer - a new therapeutic opportunity. Nat Rev Cancer.
5:505–515. 2005. View
Article : Google Scholar : PubMed/NCBI
|
12
|
Zhao J and Guan JL: Signal transduction by
focal adhesion kinase in cancer. Cancer Metastasis Rev. 28:35–49.
2009. View Article : Google Scholar : PubMed/NCBI
|
13
|
Cance WG, Harris JE, Iacocca MV, Roche E,
Yang X, Chang J, Simkins S and Xu L: Immunohistochemical analyses
of focal adhesion kinase expression in benign and malignant human
breast and colon tissues: correlation with preinvasive and invasive
phenotypes. Clin Cancer Res. 6:2417–2423. 2000.PubMed/NCBI
|
14
|
Glukhova M, Koteliansky V, Sastre X and
Thiery JP: Adhesion systems in normal breast and in invasive breast
carcinoma. Am J Pathol. 146:706–716. 1995.PubMed/NCBI
|
15
|
Gutenberg A, Brück W, Buchfelder M and
Ludwig HC: Expression of tyrosine kinases FAK and Pyk2 in 331 human
astrocytomas. Acta Neuropathol. 108:224–230. 2004.PubMed/NCBI
|
16
|
Han NM, Fleming RY, Curley SA and Gallick
GE: Overexpression of focal adhesion kinase (p125FAK) in human
colorectal carcinoma liver metastases: independence from c-src or
c-yes activation. Ann Surg Oncol. 4:264–268. 1997. View Article : Google Scholar : PubMed/NCBI
|
17
|
Hsu NY, Chen CY, Hsu CP, Lin TY, Chou MC,
Chiou SH and Chow KC: Prognostic significance of expression of
nm23-H1 and focal adhesion kinase in non-small cell lung cancer.
Oncol Rep. 18:81–85. 2007.PubMed/NCBI
|
18
|
Kornberg LJ: Focal adhesion kinase
expression in oral cancers. Head Neck. 20:634–639. 1998. View Article : Google Scholar : PubMed/NCBI
|
19
|
Owens LV, Xu L, Craven RJ, Dent GA, Weiner
TM, Kornberg L, Liu ET and Cance WG: Overexpression of the focal
adhesion kinase (p125FAK) in invasive human tumors. Cancer Res.
55:2752–2755. 1995.PubMed/NCBI
|
20
|
Cordes N, Frick S, Brunner TB, Pilarsky C,
Grützmann R, Sipos B, Kloppel G, McKenna WG and Bernhard EJ: Human
pancreatic tumor cells are sensitized to ionizing radiation by
knockdown of caveolin-1. Oncogene. 26:6851–6862. 2007. View Article : Google Scholar : PubMed/NCBI
|
21
|
Eke I and Cordes N: Dual targeting of EGFR
and focal adhesion kinase in 3D grown HNSCC cell cultures.
Radiother Oncol. 99:279–286. 2011. View Article : Google Scholar : PubMed/NCBI
|
22
|
Hehlgans S, Eke I and Cordes N: Targeting
FAK radiosensitizes 3-dimensional grown human HNSCC cells through
reduced Akt1 and MEK1/2 signaling. Int J Radiat Oncol Biol Phys.
83:e669–e676. 2012. View Article : Google Scholar : PubMed/NCBI
|
23
|
Hehlgans S, Lange I, Eke I and Cordes N:
3D cell cultures of human head and neck squamous cell carcinoma
cells are radiosensitized by the focal adhesion kinase inhibitor
TAE226. Radiother Oncol. 92:371–378. 2009. View Article : Google Scholar : PubMed/NCBI
|
24
|
Wu ZM, Yuan XH, Jiang PC, Li ZQ and Wu T:
Antisense oligonucleodes targeting the focal adhesion kinase
inhibit proliferation, induce apoptosis and cooperate with
cytotoxic drugs in human glioma cells. J Neurooncol. 77:117–123.
2006. View Article : Google Scholar
|
25
|
Storch K, Eke I, Borgmann K, Krause M,
Richter C, Becker K, Schröck E and Cordes N: Three-dimensional cell
growth confers radioresistance by chromatin density modification.
Cancer Res. 70:3925–3934. 2010. View Article : Google Scholar : PubMed/NCBI
|
26
|
Günther HS, Schmidt NO, Phillips HS,
Kemming D, Kharbanda S, Soriano R, Modrusan Z, Meissner H, Westphal
M and Lamszus K: Glioblastoma-derived stem cell-enriched cultures
form distinct subgroups according to molecular and phenotypic
criteria. Oncogene. 27:2897–2909. 2008. View Article : Google Scholar
|
27
|
Wang ZG, Fukazawa T, Nishikawa T, Watanabe
N, Sakurama K, Motoki T, Takaoka M, Hatakeyama S, Omori O, Ohara T,
Tanabe S, Fujiwara Y, Shirakawa Y, Yamatsuji T, Tanaka N and
Naomoto Y: TAE226, a dual inhibitor for FAK and IGF-IR, has
inhibitory effects on mTOR signaling in esophageal cancer cells.
Oncol Rep. 20:1473–1477. 2008.PubMed/NCBI
|
28
|
Beierle EA, Trujillo A, Nagaram A,
Golubovskaya VM, Cance WG and Kurenova EV: TAE226 inhibits human
neuroblastoma cell survival. Cancer Invest. 26:145–151. 2008.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Watanabe N, Takaoka M, Sakurama K, Tomono
Y, Hatakeyama S, Ohmori O, Motoki T, Shirakawa Y, Yamatsuji T,
Haisa M, Matsuoka J, Beer DG, Nagatsuka H, Tanaka N and Naomoto Y:
Dual tyrosine kinase inhibitor for focal adhesion kinase and
insulin-like growth factor-I receptor exhibits anticancer effect in
esophageal adenocarcinoma in vitro and in vivo. Clin Cancer Res.
14:4631–4639. 2008. View Article : Google Scholar : PubMed/NCBI
|
30
|
Golubovskaya VM, Virnig C and Cance WG:
TAE226-induced apoptosis in breast cancer cells with overexpressed
Src or EGFR. Mol Carcinog. 47:222–234. 2008. View Article : Google Scholar
|