miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression

  • Authors:
    • Ya-Sai Yao
    • Wen-Sheng Qiu
    • Ru-Yong Yao
    • Qian Zhang
    • Li‑Kun Zhuang
    • Fei Zhou
    • Li-Bin Sun
    • Lu Yue
  • View Affiliations

  • Published online on: March 18, 2015     https://doi.org/10.3892/or.2015.3866
  • Pages: 2504-2512
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Resistance to docetaxel, a chemotherapy drug for breast cancer (BC) treatment, occurs in ~50% of patients, and the underlying molecular mechanisms of drug resistance are not fully understood. Gene regulation through miR-141 has been proven to play an important role in cancer drug resistance. The present study investigated the role of miR-141 expression in BC cells of acquired docetaxel resistance. Inhibition of miR-141 enhanced the response to docetaxel in docetaxel‑resistant cells (MCF-7/DTX and MDA-MB‑231/DTX, respectively), whereas overexpression of miR-141 confered resistance in docetaxel-sensitive cells (MCF-7 and MDA-MB-231, respectively). By directly targeting the eukaryotic translation initiation factor 4E (EIF4E) mRNA, miR-141 acts on genes that are necessary for drug induced apoptosis rendering the cells drug resistant. Modulation of miR-141 expression was correlated with EIF4E expression changes and a direct interaction of miR-141 with EIF4E was shown by a luciferase assay. Thus, the present study is the first to show an increased expression of miR-141 in an acquired model of docetaxel resistance in BC. This serves as a mechanism of acquired docetaxel resistance in BC cells, possibly through direct interactions with EIF4E, therefore presenting a potential therapeutic target for the treatment of docetaxel resistant BC.
View Figures
View References

Related Articles

Journal Cover

May-2015
Volume 33 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yao Y, Qiu W, Yao R, Zhang Q, Zhuang LK, Zhou F, Sun L and Yue L: miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression. Oncol Rep 33: 2504-2512, 2015
APA
Yao, Y., Qiu, W., Yao, R., Zhang, Q., Zhuang, L., Zhou, F. ... Yue, L. (2015). miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression. Oncology Reports, 33, 2504-2512. https://doi.org/10.3892/or.2015.3866
MLA
Yao, Y., Qiu, W., Yao, R., Zhang, Q., Zhuang, L., Zhou, F., Sun, L., Yue, L."miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression". Oncology Reports 33.5 (2015): 2504-2512.
Chicago
Yao, Y., Qiu, W., Yao, R., Zhang, Q., Zhuang, L., Zhou, F., Sun, L., Yue, L."miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression". Oncology Reports 33, no. 5 (2015): 2504-2512. https://doi.org/10.3892/or.2015.3866