MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT

Retraction in: /10.3892/or.2021.8199

  • Authors:
    • Qiang Zhao
    • Ying-Xian Zhai
    • Huan-Qiu Liu
    • Ying-Ai Shi
    • Xin-Bai Li
  • View Affiliations

  • Published online on: May 28, 2015     https://doi.org/10.3892/or.2015.4013
  • Pages: 979-986
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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to regulate a variety of biological processes by targeting messenger RNA. MicroRNA-491-5p (miR-491-5p), an important miRNA, has been demonstrated to be involved in the processes of initiation and progression in several tumors. However, the precise biological function of miR-491-5p and its molecular mechanism in cervical cancer cells remain elusive. The present study was carried out to investigate the clinical significance and prognostic value of miR-491-5p expression in cervical cancer, and to evaluate the role of miR-491-5p and the underlying molecular mechanisms involved in cervical cancer. The results showed that miR-491-5p expression was significantly downregulated in cervical cancer tissues when compared with the corresponding adjacent normal tissues (P<0.001), and the value was negatively associated with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, high histological grading and lymph node metastasis (P<0.01). The enforced expression of miR-491-5p in cervical cancer cells significantly inhibited proliferation, migration and invasion, induced cell apoptosis, and suppressed the tumor growth of the mouse model of HeLa cells. In addition, the dual-luciferase reporter assay revealed that human telomerase reverse transcriptase (hTERT) was identified as a novel target gene of miR-491-5p. Notably, it was found that miR-491-5p regulated the PI3K/AKT signaling pathway. These results suggested that targeting miR-491-5p is a strategy for blocking the development of cervical cancer.
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August-2015
Volume 34 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhao Q, Zhai Y, Liu H, Shi Y and Li X: MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199. Oncol Rep 34: 979-986, 2015
APA
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., & Li, X. (2015). MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199. Oncology Reports, 34, 979-986. https://doi.org/10.3892/or.2015.4013
MLA
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., Li, X."MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199". Oncology Reports 34.2 (2015): 979-986.
Chicago
Zhao, Q., Zhai, Y., Liu, H., Shi, Y., Li, X."MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT Retraction in /10.3892/or.2021.8199". Oncology Reports 34, no. 2 (2015): 979-986. https://doi.org/10.3892/or.2015.4013