Open Access

Genetics, diagnosis and management of colorectal cancer (Review)

  • Authors:
    • Marina De Rosa
    • Ugo Pace
    • Daniela Rega
    • Valeria Costabile
    • Francesca Duraturo
    • Paola Izzo
    • Paolo Delrio
  • View Affiliations

  • Published online on: July 3, 2015     https://doi.org/10.3892/or.2015.4108
  • Pages: 1087-1096
  • Copyright: © De Rosa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. Surgery represents the mainstay of treatment in early cases but often patients are primarily diagnosed in an advanced stage of disease and sometimes also distant metastases are present. Neoadjuvant therapy is therefore needed but drug resistance may influence response and concur to recurrent disease. At molecular level, it is a very heterogeneous group of diseases with about 30% of hereditary or familial cases. During colorectal adenocarcinomas development, epithelial cells from gastrointestinal trait acquire sequential genetic and epigenetic mutations in specific oncogenes and/or tumour suppressor genes, causing CRC onset, progression and metastasis. Molecular characterization of cancer associated mutations gives valuable information about disease prognosis and response to the therapy. Very early diagnosis and personalised care, as well as a better knowledge of molecular basis of its onset and progression, are therefore crucial to obtain a cure of CRC. In this review, we describe updated genetics, current diagnosis and management of CRC pointing out the extreme need for a multidisciplinary approach to achieve the best results in patient outcomes.
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September-2015
Volume 34 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
De Rosa M, Pace U, Rega D, Costabile V, Duraturo F, Izzo P and Delrio P: Genetics, diagnosis and management of colorectal cancer (Review). Oncol Rep 34: 1087-1096, 2015
APA
De Rosa, M., Pace, U., Rega, D., Costabile, V., Duraturo, F., Izzo, P., & Delrio, P. (2015). Genetics, diagnosis and management of colorectal cancer (Review). Oncology Reports, 34, 1087-1096. https://doi.org/10.3892/or.2015.4108
MLA
De Rosa, M., Pace, U., Rega, D., Costabile, V., Duraturo, F., Izzo, P., Delrio, P."Genetics, diagnosis and management of colorectal cancer (Review)". Oncology Reports 34.3 (2015): 1087-1096.
Chicago
De Rosa, M., Pace, U., Rega, D., Costabile, V., Duraturo, F., Izzo, P., Delrio, P."Genetics, diagnosis and management of colorectal cancer (Review)". Oncology Reports 34, no. 3 (2015): 1087-1096. https://doi.org/10.3892/or.2015.4108