Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163

  • Authors:
    • Izabela Lapuc
    • Lukasz Bolkun
    • Andrzej Eljaszewicz
    • Malgorzata Rusak
    • Ewa Luksza
    • Paulina Singh
    • Paula Miklasz
    • Jaroslaw Piszcz
    • Katarzyna Ptaszynska‑Kopczynska
    • Malgorzata Jasiewicz
    • Karol Kaminski
    • Milena Dabrowska
    • Anna Bodzenta-Lukaszyk
    • Janusz Kloczko
    • Marcin Moniuszko
  • View Affiliations

  • Published online on: June 26, 2015     https://doi.org/10.3892/or.2015.4088
  • Pages: 1269-1278
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Abstract

Three main monocyte subsets: classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++, differentially regulate tumor growth and survival. Thereby, in the present study we aimed to determine the role of distinct monocyte subsets in the prognostication of chronic lymphocytic leukemia (CLL). Moreover, we set out to analyze the effects of standard immune chemotherapy on different monocyte subsets and levels of membrane-associated and soluble forms of CD163, a monocyte/macrophage-related immunomodulatory protein. We demonstrated that the number of peripheral blood classical CD14++CD16- monocytes assessed at the time of diagnosis was negatively correlated with lymphocytosis and was decreased in the CLL patients who required immediate treatment as opposed to patients who qualified to ‘watch and wait’ strategy. Notably, lower baseline levels of classical CD14++CD16- monocytes in CLL patients who were qualified for ‘watch and wait’ therapy were associated with shorter time to initial treatment. Notably, therapy with rituximab, cyclophosphamide and fludarabine resulted in a significant reduction in the number of non-classical CD14+CD16++ monocytes and soluble form of CD163 but upregulation of membrane-associated monocyte CD163. Our data indicate that distinct monocyte subsets and two forms of CD163 are differentially modulated by both CLL and immune chemotherapy. Moreover, we proposed that quantification of classical monocytes at the time of diagnosis contributes to better prognostication of CLL patients.
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September-2015
Volume 34 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lapuc I, Bolkun L, Eljaszewicz A, Rusak M, Luksza E, Singh P, Miklasz P, Piszcz J, Ptaszynska‑Kopczynska K, Jasiewicz M, Jasiewicz M, et al: Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163. Oncol Rep 34: 1269-1278, 2015
APA
Lapuc, I., Bolkun, L., Eljaszewicz, A., Rusak, M., Luksza, E., Singh, P. ... Moniuszko, M. (2015). Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163. Oncology Reports, 34, 1269-1278. https://doi.org/10.3892/or.2015.4088
MLA
Lapuc, I., Bolkun, L., Eljaszewicz, A., Rusak, M., Luksza, E., Singh, P., Miklasz, P., Piszcz, J., Ptaszynska‑Kopczynska, K., Jasiewicz, M., Kaminski, K., Dabrowska, M., Bodzenta-Lukaszyk, A., Kloczko, J., Moniuszko, M."Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163". Oncology Reports 34.3 (2015): 1269-1278.
Chicago
Lapuc, I., Bolkun, L., Eljaszewicz, A., Rusak, M., Luksza, E., Singh, P., Miklasz, P., Piszcz, J., Ptaszynska‑Kopczynska, K., Jasiewicz, M., Kaminski, K., Dabrowska, M., Bodzenta-Lukaszyk, A., Kloczko, J., Moniuszko, M."Circulating classical CD14++CD16- monocytes predict shorter time to initial treatment in chronic lymphocytic leukemia patients: Differential effects of immune chemotherapy on monocyte-related membrane and soluble forms of CD163". Oncology Reports 34, no. 3 (2015): 1269-1278. https://doi.org/10.3892/or.2015.4088