miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6

Retraction in: /10.3892/or.2021.8097

  • Authors:
    • Qiang Wen
    • Jie Zhao
    • Lin Bai
    • Tongtong Wang
    • Haishan Zhang
    • Qingjie Ma
  • View Affiliations

  • Published online on: July 31, 2015     https://doi.org/10.3892/or.2015.4165
  • Pages: 2202-2210
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Abstract

microRNA-126 (miR-126) has been reported to play tumor suppressor roles in various types of cancers. Although it has been reported that miR-126 expression is downregulated in papillary thyroid carcinoma (PTC), the precise role and underlying molecular mechanism of miR-126 in PTC remains unclear. Therefore, the aims of the present study were to investigate the role and potential mechanism of miR-126 in tumorigenicity of PTC in vivo and in vitro. We observed that the miR-126 expression level was significantly downregulated in PTC tissue and PTC cell lines, the aberrant expression of miR-126 was correlated with lymph node metastasis, tumor size and TNM stage. We also showed that restoration of miR-126 in PTC cells inhibited cell proliferation, colony formations, migration and invasion, promoted cell apoptosis and cell cycle arrest at G1 stage in vitro, as well as inhibited tumor growth and decreased tumor volume and weight in vivo. Furthermore, low-density lipoprotein receptor‑related protein 6 (LRP6), a regulator of the Wnt/β‑catenin signaling cascade, was identified as a crucial target gene of miR-126. Overexpression of miR-126 inhibited LP6 expression on mRNA and protein levels, and deactivate Wnt/β-catenin signaling pathway. These results suggested that miR-126 functions as a tumor-suppressive miRNA by targeting LRP6 regulating Wnt/β-catenin signaling pathway and represents a therapeutic target for PTC.
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October-2015
Volume 34 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wen Q, Zhao J, Bai L, Wang T, Zhang H and Ma Q: miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6 Retraction in /10.3892/or.2021.8097. Oncol Rep 34: 2202-2210, 2015
APA
Wen, Q., Zhao, J., Bai, L., Wang, T., Zhang, H., & Ma, Q. (2015). miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6 Retraction in /10.3892/or.2021.8097. Oncology Reports, 34, 2202-2210. https://doi.org/10.3892/or.2015.4165
MLA
Wen, Q., Zhao, J., Bai, L., Wang, T., Zhang, H., Ma, Q."miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6 Retraction in /10.3892/or.2021.8097". Oncology Reports 34.4 (2015): 2202-2210.
Chicago
Wen, Q., Zhao, J., Bai, L., Wang, T., Zhang, H., Ma, Q."miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6 Retraction in /10.3892/or.2021.8097". Oncology Reports 34, no. 4 (2015): 2202-2210. https://doi.org/10.3892/or.2015.4165