Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes

  • Authors:
    • Yan Jia
    • Jun Chen
    • He Zhu
    • Zan-Hui Jia
    • Man-Hua Cui
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  • Published online on: August 20, 2015     https://doi.org/10.3892/or.2015.4214
  • Pages: 2296-2304
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Abstract

The presence of cancer stem cells in cervical cancer stem cells (CSCs) is important in the prevention of therapy failure and tumor recurrence. Upregulation of transcriptional regulation of redox sensing factor Nrf2 leads to the overexpression of drug efflux proteins such as ABCG2 in cancer stem cells and thus results in cancer treatment failure and cancer relapse. In the present study, we purified approximately 3.1% of cervical CSCs, which exhibited aberrant upregulation of Nrf2 in conjunction with an elevated transcriptional regulation of ABCG2, Bcl-2 and Bmi-1. Consequently, CSCs possess prolonged cell survival, infinite cell proliferation and highly resistant apoptosis. Following silencing of the function of Nrf2 the cervical CSCs became more sensitive to DNA targeting drugs and apoptosis. Our results suggested that Nrf2-mediated drug and apoptosis resistance are important in cancer therapies and tumor recurrence. Therefore, designing anticancer drugs targeting Nrf2 may be crucial to prevent CSC-mediated tumorigenesis.
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November-2015
Volume 34 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jia Y, Chen J, Zhu H, Jia Z and Cui M: Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes. Oncol Rep 34: 2296-2304, 2015
APA
Jia, Y., Chen, J., Zhu, H., Jia, Z., & Cui, M. (2015). Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes. Oncology Reports, 34, 2296-2304. https://doi.org/10.3892/or.2015.4214
MLA
Jia, Y., Chen, J., Zhu, H., Jia, Z., Cui, M."Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes". Oncology Reports 34.5 (2015): 2296-2304.
Chicago
Jia, Y., Chen, J., Zhu, H., Jia, Z., Cui, M."Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes". Oncology Reports 34, no. 5 (2015): 2296-2304. https://doi.org/10.3892/or.2015.4214