MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7

Corrigendum in: /10.3892/or.2023.8596

  • Authors:
    • Wei Yang
    • Changwei Dou
    • Yufeng Wang
    • Yuli Jia
    • Chao Li
    • Xin Zheng
    • Kangsheng Tu
  • View Affiliations

  • Published online on: August 19, 2015     https://doi.org/10.3892/or.2015.4210
  • Pages: 2576-2584
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Abstract

Deregulation of microRNA-92a (miR-92a) has been reported in several human cancers and is associated with prognosis of patients. However, the clinical significance of miR-92a and the underlying mechanisms involved in hepatocarcinogenesis remain to be determined. The aim of the present study was to determine the role of miR-92a in hepatocellular carcinoma (HCC). The results showed that the expression of miR-92a was upregulated in HCC tissues as compared with matched tumor-adjacent tissues. A high expression of miR-92a was observed in HCC cell lines as compared with a non-transformed hepatic cell line. The gain- and loss-of-function studies revealed that miR-92a significantly promoted proliferation and cell cycle transition from G1 to S phase, and inhibited apoptosis of HCC cell in vitro. In tumor‑bearing nude mice, the downregulation of miR-92a suppressed tumor growth of HCC in vivo. miR-92a was inversely correlated with F-box and WD repeat domain-containing 7 (FBXW7) expression in HCC tissues. Furthermore, miR-92a negatively regulated FBXW7 abundance in HCC cells. In the present study, FBXW7 was identified as a direct target of miR-92a. Notably, alterations of FBXW7 expression abrogated the effects of miR-92a on HCC cell proliferation, cell cycle and apoptosis. Clinical association analysis revealed that a high expression of miR-92a was correlated with poor prognostic characteristics of HCC. Notably, the high expression of miR-92a conferred a reduced 5-year overall survival (OS) and recurrence-free survival (RFS) of HCC patients. The multivariate Cox regression analysis demonstrated that miR-92a expression was an independent prognostic marker for predicting survival of HCC patients. In conclusion, the results of the present study suggested that miR-92a promotes the tumor growth of HCC by targeting FBXW7 and may serve as a novel prognostic biomarker and therapeutic target for HCC.
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November-2015
Volume 34 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yang W, Dou C, Wang Y, Jia Y, Li C, Zheng X and Tu K: MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7 Corrigendum in /10.3892/or.2023.8596. Oncol Rep 34: 2576-2584, 2015
APA
Yang, W., Dou, C., Wang, Y., Jia, Y., Li, C., Zheng, X., & Tu, K. (2015). MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7 Corrigendum in /10.3892/or.2023.8596. Oncology Reports, 34, 2576-2584. https://doi.org/10.3892/or.2015.4210
MLA
Yang, W., Dou, C., Wang, Y., Jia, Y., Li, C., Zheng, X., Tu, K."MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7 Corrigendum in /10.3892/or.2023.8596". Oncology Reports 34.5 (2015): 2576-2584.
Chicago
Yang, W., Dou, C., Wang, Y., Jia, Y., Li, C., Zheng, X., Tu, K."MicroRNA-92a contributes to tumor growth of human hepatocellular carcinoma by targeting FBXW7 Corrigendum in /10.3892/or.2023.8596". Oncology Reports 34, no. 5 (2015): 2576-2584. https://doi.org/10.3892/or.2015.4210