Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway

  • Authors:
    • Qi Li
    • Yiming Lai
    • Chengbin Wang
    • Guibin Xu
    • Zheng He
    • Xiaohong Shang
    • Yi Sun
    • Fan Zhang
    • Leyuan Liu
    • Hai Huang
  • View Affiliations

  • Published online on: October 21, 2015     https://doi.org/10.3892/or.2015.4341
  • Pages: 375-381
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Abstract

Matrine is a naturally occurring alkaloid extracted from the Chinese herb Sophora flavescens. It has been demon­strated to exhibit antiproliferative properties, promote apoptosis and inhibit cell invasion in a number of cancer cell lines. It has also been shown to improve the efficacy of chemotherapy when it is combined with other chemotherapy drugs. However, the therapeutic efficacy of matrine for prostate cancer remains poorly understood. In the present study, we showed that matrine inhibited the proliferation, migration and invasion of both DU145 and PC-3 cells in a dose- and time-dependent manner. It also reduced the cell population at S phase and increased the cell population at sub-G1 phase. The increases in both the apoptotic cell population and cell population at S and sub-G1 phases consistently indicated a pro-apoptotic effect of matrine. Decreases in levels of P65, p-P65, IKKα/β, p-IKKα/β, IKBα and p-IKBα as detected by immunoblot analysis in the matrine-treated DU145 and PC-3 cells suggested an involvement of the NF‑κB signaling pathway. Therefore, it is a novel promising addition to the current arsenal of chemotherapy drugs for the treatment of androgen-independent prostate cancer.
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January-2016
Volume 35 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li Q, Lai Y, Wang C, Xu G, He Z, Shang X, Sun Y, Zhang F, Liu L, Huang H, Huang H, et al: Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway. Oncol Rep 35: 375-381, 2016
APA
Li, Q., Lai, Y., Wang, C., Xu, G., He, Z., Shang, X. ... Huang, H. (2016). Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway. Oncology Reports, 35, 375-381. https://doi.org/10.3892/or.2015.4341
MLA
Li, Q., Lai, Y., Wang, C., Xu, G., He, Z., Shang, X., Sun, Y., Zhang, F., Liu, L., Huang, H."Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway". Oncology Reports 35.1 (2016): 375-381.
Chicago
Li, Q., Lai, Y., Wang, C., Xu, G., He, Z., Shang, X., Sun, Y., Zhang, F., Liu, L., Huang, H."Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway". Oncology Reports 35, no. 1 (2016): 375-381. https://doi.org/10.3892/or.2015.4341