Expression of alpha-smooth-muscle actin antigen in thymoma and thymic cancer

  • Authors:
    • Y Ohta
    • N Ishikawa
    • S Murakami
    • M Oda
    • Y Endo
    • T Sasaki
    • Y Watanabe
  • View Affiliations

  • Published online on: Monday, September 1, 1997
  • Pages: 893-897
  • DOI: 10.3892/or.4.5.893

Abstract

Using specimens from 95 patients with thymoma and 6 with thymic cancer, we studied the expression of an alpha-smooth-muscle actin antigen immunohistochemically. It was mainly identified in the cytoplasm of small spindle cells within stroma and in the cytoplasm of tumor cells excepting vessels. In thymomas, the stromal expression is related to poor survival, while the cytoplasmic expression within tumor cells correlate with good outcome. Our data indicate that significance of the smooth muscle differentiation may be different between stromal and tumor cells. This antigen may be a useful indicator of survival in thymic neoplasms, especially in thymoma.
Journal Cover

September 1997
Volume 4 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Ohta, Y., Ishikawa, N., Murakami, S., Oda, M., Endo, Y., Sasaki, T., & Watanabe, Y. (1997). Expression of alpha-smooth-muscle actin antigen in thymoma and thymic cancer. Oncology Reports, 4(5), 893-897.
MLA
Ohta, Ishikawa, Murakami, Oda, Endo, Sasaki, and Y Watanabe. "Expression of alpha-smooth-muscle actin antigen in thymoma and thymic cancer." Oncology Reports Oncology Reports 4.5 (1997): 893-897.
Chicago
Ohta, Ishikawa, Murakami, Oda, Endo, Sasaki, and Y Watanabe. "Expression of alpha-smooth-muscle actin antigen in thymoma and thymic cancer." Oncology Reports Oncology Reports 4 no. 5 (1997): 893-897.