|Human chorionic gonadotropin as a target for cancer vaccines.|
Authors: P L Triozzi, V C Stevens
Affiliations: The Ohio State University Comprehensive Cancer Center, The Arthur G. James Cancer Hospital and Research Institute, Columbus, OH 43210, USA.
Human chorionic gonadotropin (hCG) is expressed by common cancers and may play a role in cell transformation as well as angiogenic, metastatic, and immune escape phenomena that are central to cancer progression. Clinical trials with a vaccine targeting the carboxy-terminal peptide of -hCG have indicated that tolerance to this oncofetal antigen can be broken. Humoral responses that may modulate the biologic activity of tumor-associated hCG as well as cellular responses to hCG have been generated. Studies are in progress to further define the biologic significance of hCG in cancer and to develop a vaccine approach that will best target this expression.