Effects of quinolinone derivative, vesnarinone, in combination with irradiation on human lung cancer cell lines.

  • Authors: M Fujita, T Tsuchida, T Fujita, K Higashino
  • View Affiliations

  • Published online on: Monday, March 1, 1999
  • Pages: 353-360
  • DOI: 10.3892/or.6.2.353

Abstract

The quinolinone derivative, vesnarinone, is a novel inotropic agent used in the treatment of heart failure. It has also been found that vesnarinone has a potential anti-cancer activity. To evaluate the anti-cancer activity of vesnarinone in combination with irradiation, we investigated the cytostatic and cytotoxic effects on human lung cancer cell lines (PC-9 and Lu 134A) using MTT assay and isobologram analysis. We also analyzed the nuclear fragmentation of tumor cells by flow cytometric analysis. Our study demonstrated that combination of vesnarinone with irradiation had an additive inhibitory effect on both PC-9 and Lu 134A tumor cell growth. Vesnarinone could improve the sensitivity of tumor cells to irradiation and thus the dose of irradiation could be reduced to half without decreased inhibitory effect. Significant increase of the tumor cell nuclear fragmentation was observed with combination of vesnarinone and irradiation. These results indicate that vesnarinone not only directly inhibited tumor cell growth, but also improved the sensitivity to irradiation. Combination of vesnarinone with irradiation may be an efficacious protocol for lung cancer treatment. The inhibitory effect was ascribed to inducing tumor cell apoptosis.
Journal Cover

March 1999
Volume 6 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Fujita, M., Tsuchida, T., Fujita, T., & Higashino, K. (1999). Effects of quinolinone derivative, vesnarinone, in combination with irradiation on human lung cancer cell lines.. Oncology Reports, 6(2), 353-360.
MLA
Fujita, Tsuchida, Fujita, and K Higashino. "Effects of quinolinone derivative, vesnarinone, in combination with irradiation on human lung cancer cell lines.." Oncology Reports Oncology Reports 6.2 (1999): 353-360.
Chicago
Fujita, Tsuchida, Fujita, and K Higashino. "Effects of quinolinone derivative, vesnarinone, in combination with irradiation on human lung cancer cell lines.." Oncology Reports Oncology Reports 6 no. 2 (1999): 353-360.