Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells.

  • Authors:
    • H Hibasami
    • T Fujikawa
    • H Takeda
    • S Nishibe
    • T Satoh
    • T Fujisawa
    • K Nakashima
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1213
  • Pages: 1213-1219
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Abstract

Antitumor effect of the stem bark of Acanthopanax senticosus HARMS (ASH) from Hokkaido (Japanese name: Ezoukogi) on human stomach cancer KATO III cells was investigated. The extract of the stem bark of ASH prepared with hot water was dissolved in distilled water and used for the assay of antitumor effect on the KATO III cells. The exposure of KATO III cells to ASH led to both growth inhibition and induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with ASH. The fragmentation by ASH of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. We have investigated which component in ASH is effective on the induction of apoptosis. Among chlorogenic acid, syringaresinol di-o-beta-D glucoside, syringin, and sesamin, components of the n-butanol extract prepared from ASH, sesamin suppressed the growth and induced apoptosis in the cells. These findings suggest that growth inhibition by ASH results from the apoptosis induced by sesamin, a component of ASH.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hibasami H, Fujikawa T, Takeda H, Nishibe S, Satoh T, Fujisawa T and Nakashima K: Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells.. Oncol Rep 7: 1213-1219, 2000
APA
Hibasami, H., Fujikawa, T., Takeda, H., Nishibe, S., Satoh, T., Fujisawa, T., & Nakashima, K. (2000). Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells.. Oncology Reports, 7, 1213-1219. https://doi.org/10.3892/or.7.6.1213
MLA
Hibasami, H., Fujikawa, T., Takeda, H., Nishibe, S., Satoh, T., Fujisawa, T., Nakashima, K."Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells.". Oncology Reports 7.6 (2000): 1213-1219.
Chicago
Hibasami, H., Fujikawa, T., Takeda, H., Nishibe, S., Satoh, T., Fujisawa, T., Nakashima, K."Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells.". Oncology Reports 7, no. 6 (2000): 1213-1219. https://doi.org/10.3892/or.7.6.1213