Biological role of thymidine phosphorylase in human astrocytic tumors

  • Authors: Koji Tanioka, Hideo Takeshima, Hirofumi Hirano, Takahiro Kimura, Shun-ichi Nagata, Shin-ichi Akiyama, Jun-ichi Kuratsu
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  • Published online on: Tuesday, May 1, 2001
  • Pages: 491-496
  • DOI: 10.3892/or.8.3.491

Abstract

Thymidine phosphorylase (TP) has strong angiogenic activity and is overexpressed in a wide variety of malignant tumors. To elucidate the role of TP in human astrocytic tumors, we immunohistochemically investigated the expression of TP in 62 astrocytic tumors (12 astrocytomas, 12 anaplastic astrocytomas and 38 glioblastomas). Fifty-five astrocytic tumors (88.7%) were immunopositive for TP. The level of TP-expression was significantly correlated with the malignancy grade of astrocytic tumors; most of malignant gliomas highly expressed TP, while a small number of cells were positive in low grade astrocytomas (p<0.001). Using double-immunostaining, we clarified that TP-expression was predominantly detectable in macrophages. There was no significant correlation between MIB-1 labeling index and TP-expression. However, TP-expression and the microvessel density were well correlated. These suggest that TP, mainly produced by the infiltrated macrophages, may play an important role in the progression of astrocytic tumors via neovascularization. Inhibitor of TP may represent a therapeutic modality for treating malignant gliomas.
Journal Cover

May 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Tanioka, K., Takeshima, H., Hirano, H., Kimura, T., Nagata, S., Akiyama, S., & Kuratsu, J. (2001). Biological role of thymidine phosphorylase in human astrocytic tumors. Oncology Reports, 8(3), 491-496.
MLA
Tanioka, Takeshima, Hirano, Kimura, Nagata, Akiyama, and Jun-ichi Kuratsu. "Biological role of thymidine phosphorylase in human astrocytic tumors." Oncology Reports Oncology Reports 8.3 (2001): 491-496.
Chicago
Tanioka, Takeshima, Hirano, Kimura, Nagata, Akiyama, and Jun-ichi Kuratsu. "Biological role of thymidine phosphorylase in human astrocytic tumors." Oncology Reports Oncology Reports 8 no. 3 (2001): 491-496.