A randomized study comparing oral and standard regimens for metastatic breast cancer

  • Authors:
    • Taisuke Hori
    • Hiroshi Kodama
    • Satoru Nishimura
    • Takehiko Hatano
    • Ryuji Okamura
    • Koji Fujii
    • Takashi Kudo
    • Takashi Inamoto
    • Kiyoshi Sawai
    • Masao Kobayashi
    • Hiroki Ogawa
    • Norio Yoshimura
    • Masahiro Hiraoka
  • Corresponding author:
  • View Affiliations

  • Published online on: Saturday, September 1, 2001
  • Pages: 1067-1071 DOI: 10.3892/or.8.5.1067

Abstract

We conducted a randomized controlled trial comparing oral regimen [doxifluridine, an intermediate metabolite of capecitabine, + medroxyprogesterone acetate (MPA) + cyclophosphamide (CPA)] (Method A) with a standard regimen (5-fluorouracil + adriamycin + CPA) plus MPA (Method B) as first line chemotherapy for metastatic breast cancer. Overall response rate was 55.8% for Method A, 46.3% for Method B. The total ratio of responder and long stable disease was significantly higher with Method A (p=0.006). Median time to progression and survival were not differences between Methods. Incidence of toxicity was 56.3% with Method A and 80.0% with Method B (p=0.014). Oral regimen is more useful than standard therapy.
Journal Cover

September 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
2014 I.F. (Expected) ≥ 2.527 Ranked #33/202 Oncology
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APA
Hori, T., Kodama, H., Nishimura, S., Hatano, T., Okamura, R., Fujii, K. ... Hiraoka, M. (2001). A randomized study comparing oral and standard regimens for metastatic breast cancer. Oncology Reports, 8, 1067-1071. http://dx.doi.org/10.3892/or.8.5.1067
MLA
Hori, T., Kodama, H., Nishimura, S., Hatano, T., Okamura, R., Fujii, K., Kudo, T., Inamoto, T., Sawai, K., Kobayashi, M., Ogawa, H., Yoshimura, N., Hiraoka, M."A randomized study comparing oral and standard regimens for metastatic breast cancer". Oncology Reports 8.5 (2001): 1067-1071.
Chicago
Hori, T., Kodama, H., Nishimura, S., Hatano, T., Okamura, R., Fujii, K., Kudo, T., Inamoto, T., Sawai, K., Kobayashi, M., Ogawa, H., Yoshimura, N., Hiraoka, M."A randomized study comparing oral and standard regimens for metastatic breast cancer". Oncology Reports 8, no. 5 (2001): 1067-1071. http://dx.doi.org/10.3892/or.8.5.1067