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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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May-2016 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals

  • Authors:
    • Feng Zhang
    • Haining Yu
    • Xiaofeng Ni
    • Jing Zhu
    • Shanshan Wang
    • Shengrong Shen

  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, P.R. China, School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China
  • Pages: 635-641
    |
    Published online on: March 2, 2016
       https://doi.org/10.3892/br.2016.621
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Abstract

Environmental pollution is a current area of focus worldwide, particularly heavy metal pollution. Feasible prevention or therapeutic strategies are required. Exploration of the correlation between ω‑3 polyunsaturated fatty acids  (ω‑3 PUFAs) and intestinal epithelial cells injured by heavy metals may be of significance for intestinal health. In the present study, the effects of ω‑3 PUFAs on the rat intestinal crypt cell line (IEC‑6) injured by heavy metals and its mechanisms were determined according to the evaluation of cell viability and expression levels of reactive oxygen species (ROS), epidermal growth factor (EGF) and interleukin‑6 (IL‑6). The results demonstrated that ω‑3 PUFAs can improve the viability of IEC‑6 cells injured by heavy metals and the expression level of ROS was correlated with oxidative damage; the increased expression level of inflammatory factors is associated with cell apoptosis. In the present study, ω‑3 PUFAs significantly decreased the expression levels of ROS, EGF and IL‑6. This indicates that the protective action of ω‑3 PUFAs was associated with a decrease of oxidative damage and pro‑inflammatory cytokine expression against the damage of heavy metals.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Yu H, Ni X, Zhu J, Wang S and Shen S: Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals. Biomed Rep 4: 635-641, 2016.
APA
Zhang, F., Yu, H., Ni, X., Zhu, J., Wang, S., & Shen, S. (2016). Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals. Biomedical Reports, 4, 635-641. https://doi.org/10.3892/br.2016.621
MLA
Zhang, F., Yu, H., Ni, X., Zhu, J., Wang, S., Shen, S."Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals". Biomedical Reports 4.5 (2016): 635-641.
Chicago
Zhang, F., Yu, H., Ni, X., Zhu, J., Wang, S., Shen, S."Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals". Biomedical Reports 4, no. 5 (2016): 635-641. https://doi.org/10.3892/br.2016.621
Copy and paste a formatted citation
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Spandidos Publications style
Zhang F, Yu H, Ni X, Zhu J, Wang S and Shen S: Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals. Biomed Rep 4: 635-641, 2016.
APA
Zhang, F., Yu, H., Ni, X., Zhu, J., Wang, S., & Shen, S. (2016). Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals. Biomedical Reports, 4, 635-641. https://doi.org/10.3892/br.2016.621
MLA
Zhang, F., Yu, H., Ni, X., Zhu, J., Wang, S., Shen, S."Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals". Biomedical Reports 4.5 (2016): 635-641.
Chicago
Zhang, F., Yu, H., Ni, X., Zhu, J., Wang, S., Shen, S."Effect of ω‑3 polyunsaturated fatty acids on the growth of IEC‑6 cells injured by heavy metals". Biomedical Reports 4, no. 5 (2016): 635-641. https://doi.org/10.3892/br.2016.621
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