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Experimental and Therapeutic Medicine
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October-2017 Volume 14 Issue 4

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Article Open Access

Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium

  • Authors:
    • Hongling Zhu
    • Xiaoyan Li
    • Mingjie Yuan
    • Weiguo Wan
    • Miaoyang Hu
    • Xiaoding Wang
    • Xuejun Jiang

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3609-3615
    |
    Published online on: August 24, 2017
       https://doi.org/10.3892/etm.2017.5015
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Abstract

Basic fibroblast growth factor (bFGF), a known angiogenic factor, may provide a potential strategy for the treatment of myocardial infarction (MI), but it is limited by a relatively short half‑life. Dex‑PCL‑HEMA/PNIPAAm hydrogel provides a reservoir for the controlled release of growth factors. The aim of the current study was to evaluate the effects of bFGF incorporated into a Dex‑PCL‑HEMA/PNIPAAm hydrogel on angiogenesis and cardiac health in a rat model of acute MI, induced by coronary artery ligation. Phosphate‑buffered solution (PBS group), Dex‑PCL‑HEMA/PNIPAAm hydrogel (Gel group), bFGF in phosphate‑buffered solution (bFGF group) or bFGF in hydrogel (Gel + bFGF group) was injected into a peri‑infarcted area of cardiac tissue immediately following MI. On day 30 post‑surgery, cardiac function was assessed by echocardiography, apoptosis index by terminal deoxynucleotidyl transferase dUTP nick‑end labeling assessment and vascular development by immunohistochemical staining. The findings demonstrated that injection of bFGF along with hydrogel induced angiogenesis, reduced collagen content, MI area and cell apoptosis and improved cardiac function compared with the injection of either bFGF or hydrogel alone. bFGF incorporated with Dex‑PCL‑HEMA/PNIPAAm hydrogel injection induces angiogenesis, attenuates cardiac remodeling and improves cardiac function following MI.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Li X, Yuan M, Wan W, Hu M, Wang X and Jiang X: Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium. Exp Ther Med 14: 3609-3615, 2017.
APA
Zhu, H., Li, X., Yuan, M., Wan, W., Hu, M., Wang, X., & Jiang, X. (2017). Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium. Experimental and Therapeutic Medicine, 14, 3609-3615. https://doi.org/10.3892/etm.2017.5015
MLA
Zhu, H., Li, X., Yuan, M., Wan, W., Hu, M., Wang, X., Jiang, X."Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium". Experimental and Therapeutic Medicine 14.4 (2017): 3609-3615.
Chicago
Zhu, H., Li, X., Yuan, M., Wan, W., Hu, M., Wang, X., Jiang, X."Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3609-3615. https://doi.org/10.3892/etm.2017.5015
Copy and paste a formatted citation
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Spandidos Publications style
Zhu H, Li X, Yuan M, Wan W, Hu M, Wang X and Jiang X: Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium. Exp Ther Med 14: 3609-3615, 2017.
APA
Zhu, H., Li, X., Yuan, M., Wan, W., Hu, M., Wang, X., & Jiang, X. (2017). Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium. Experimental and Therapeutic Medicine, 14, 3609-3615. https://doi.org/10.3892/etm.2017.5015
MLA
Zhu, H., Li, X., Yuan, M., Wan, W., Hu, M., Wang, X., Jiang, X."Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium". Experimental and Therapeutic Medicine 14.4 (2017): 3609-3615.
Chicago
Zhu, H., Li, X., Yuan, M., Wan, W., Hu, M., Wang, X., Jiang, X."Intramyocardial delivery of bFGF with a biodegradable and thermosensitive hydrogel improves angiogenesis and cardio‑protection in infarcted myocardium". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3609-3615. https://doi.org/10.3892/etm.2017.5015
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