Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2026 Volume 31 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2026 Volume 31 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis

  • Authors:
    • Xianchao Ding
    • Daoming Shi
    • Jieru Wang
    • Honghua Cai
    • Zhixin Yan
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China
  • Article Number: 179
    |
    Published online on: April 28, 2026
       https://doi.org/10.3892/etm.2026.13174
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

The clinical efficacy of dexmedetomidine (Dex) in acute lung injury (ALI) and its related molecular mechanisms in human systems are poorly defined. In the present study the modulatory functions of Dex in human ALI were investigated, together with identification of the key molecular pathways involved. Human respiratory epithelial cell lines (A549 and BEAS2b) were cultured in vitro and categorized into four experimental groups: Untreated control (Con), Dex‑treated, lipopolysaccharide (LPS)‑treated, and both LPS + Dex‑treated (LPS + Dex) groups. In BEAS‑2B cells, inflammatory cytokine levels in the culture supernatant and cell viability were measured in all groups. In A549 cells, proliferative capacity and apoptosis rates were evaluated. The mRNA levels of caspase‑3 and BCL‑2, BAX within the BEAS‑2B cells after LPS exposure were examined using reverse transcription‑quantitative PCR. The levels of Janus kinase 1 (JAK1) and signal transduction and transcription activation 3 (STAT3) proteins, along with their phosphorylated forms in A549 cells, were analyzed via western blotting. Dex substantially suppressed LPS‑mediated elevation of IL‑1β, IL‑6 and TNF‑α. LPS‑associated reductions in cell viability and proliferative activity were markedly attenuated following Dex treatment. It also lowered the LPS‑induced increase in apoptotic cell populations. The upregulation of caspase‑3 and BAX gene expression after LPS stimulation in BEAS‑2B cells was decreased by Dex treatment. The downregulation of BCL‑2 gene expression after LPS stimulation in BEAS‑2B cells was alleviated by Dex treatment. Moreover, Dex suppressed LPS‑induced stimulation of the JAK1/STAT3 signaling cascade, as evidenced by downregulation of phosphorylated (p‑)STAT3 and p‑JAK1 in the A549 cells. Dex showed a protective effect against human ALI in vitro by reducing inflammatory responses, maintaining epithelial cell viability and decreasing apoptosis rate of epithelial cell. Modulation of the JAK1/STAT3 signaling cascade plays a crucial role in mediating these effects.
View Figures

Figure 1

Dex suppresses LPS-induced
inflammation in BEAS-2B cells. (A) IL-1β, (B) IL-6, and (C) TNF-α.
Data are expressed as mean ± SD (n=3). *P<0.05,
**P<0.01. Dex dexmedetomidine; LPS,
lipopolysaccharide.

Figure 2

Influence of Dex on cell viability
after LPS exposure. Cell viability of BEAS-2B cells was assessed at
different time points under different treatment conditions. Data
are expressed as mean ± SD (n=4). *P<0.05,
**P<0.01. Dex dexmedetomidine; LPS,
lipopolysaccharide.

Figure 3

Dex attenuates inhibition of A549
cell propagation induced by LPS. (A) Representative images of
colony formation assays under different treatment conditions. (B)
Quantification of colony numbers. Data are expressed as mean ± SD
(n=3). *P<0.05, **P<0.01. Dex
dexmedetomidine; LPS, lipopolysaccharide.

Figure 4

Dex reduces apoptosis induced by LPS
in A549 cells. (A) TUNEL staining of A549 cells following different
treatments (scale bar, 100 µm). (B) Quantification of apoptotic
cell rates in all groups. Data are expressed as mean ± SD (n=3).
**P<0.01, ***P<0.001. Dex
dexmedetomidine; LPS, lipopolysaccharide.

Figure 5

Dex modulates apoptosis-related gene
level in LPS-stimulated A549 cells. #P<0.05 vs. LPS
group, **P<0.01 vs. Control. Dex dexmedetomidine;
LPS, lipopolysaccharide.

Figure 6

Dex modulates apoptosis-related gene
level in LPS-stimulated A549 cells. (A) Western blotting images of
JAK1, p-JAK1, and GAPDH. (B) Densitometric analysis of relative
protein expression levels. (C) Western blotting images of STAT3,
p-STAT3, and GAPDH. (D) Quantification of relative STAT3 and
p-STAT3 levels. Data are mean ± SD. *P<0.05,
**P<0.01. Dex dexmedetomidine; LPS,
lipopolysaccharide; JAK1, Janus kinase 1; p-, phosphorylated;
STAT3, signal transduction and transcription activation 3.
View References

1 

Yadav H, Thompson BT and Gajic O: Fifty years of research in ARDS. Is acute respiratory distress syndrome a preventable disease? Am J Respir Crit Care Med. 195:725–736. 2017.PubMed/NCBI View Article : Google Scholar

2 

Yang X, Li J, Ma Y, Dong X, Qu J, Liang F and Liu J: Curcumin-mediated enhancement of lung barrier function in rats with high-altitude-associated acute lung injury via inhibition of inflammatory response. Respir Res. 25(354)2024.PubMed/NCBI View Article : Google Scholar

3 

Zhang L, Li H, Li D and Dai Q: Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (review). Mol Med Rep. 33(31)2026.PubMed/NCBI View Article : Google Scholar

4 

Ding ZL, Ma YC, Liu CM, Lu X, Wang RR, Tang MM, Hua DX, Zheng L, Zhao H and Fu L: 1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells. Front Pharmacol. 17(1723593)2026.PubMed/NCBI View Article : Google Scholar

5 

Wu J, Ye J, Kong W, Zhang S and Zheng Y: Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 53(e12915)2020.PubMed/NCBI View Article : Google Scholar

6 

Long ME, Mallampalli RK and Horowitz JC: Pathogenesis of pneumonia and acute lung injury. Clin Sci (Lond). 136:747–769. 2022.PubMed/NCBI View Article : Google Scholar

7 

Guo H, Guan J, Wu X, Wei Y, Zhao J, Zhou Y, Li F and Pang HB: Peptide-guided delivery improves the therapeutic efficacy and safety of glucocorticoid drugs for treating acute lung injury. Mol Ther. 31:875–889. 2023.PubMed/NCBI View Article : Google Scholar

8 

Yang S, Song Y, Wang Q, Liu Y, Wu Z, Duan X, Zhang Y, Bi X, Geng Y, Chen S and Zhu C: Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway. Sci Rep. 11(11491)2021.PubMed/NCBI View Article : Google Scholar

9 

Chen IC, Wang SC, Chen YT, Tseng HH, Liu PL, Lin TC, Wu HE, Chen YR, Tseng YH, Hsu JH, et al: Corylin ameliorates LPS-induced acute lung injury via suppressing the MAPKs and IL-6/STAT3 signaling pathways. Pharmaceuticals (Basel). 14(1046)2021.PubMed/NCBI View Article : Google Scholar

10 

Zhu L, Wu H, Ma Z, Dong D, Yang Z and Tian J: Astaxanthin ameliorates lipopolysaccharide-induced acute lung injury via inhibition of inflammatory reactions and modulation of the SOCS3/JAK2/STAT3 signaling pathways in mice. Food Funct. 13:11638–11651. 2022.PubMed/NCBI View Article : Google Scholar

11 

Wang K, Wu M, Xu J, Wu C, Zhang B, Wang G and Ma D: Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: Systematic review and meta-analysis. Br J Anaesth. 123:777–794. 2019.PubMed/NCBI View Article : Google Scholar

12 

Zhang Q, Huang Y, Gong C, Tang Y, Xiong J, Wang D and Liu X: Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis. Immun Inflamm Dis. 11(e883)2023.PubMed/NCBI View Article : Google Scholar

13 

Shi J, Yu T, Song K, Du S, He S, Hu X, Li X, Li H, Dong S, Zhang Y, et al: Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway. Redox Biol. 41(101954)2021.PubMed/NCBI View Article : Google Scholar

14 

Li F, Bai Y, Guan Z, Ji X, Zhan X, Gao Y, Zhong W and Rao Z: Dexmedetomidine attenuates sepsis-associated acute lung injury by regulating macrophage efferocytosis through the ROS/ADAM10/AXL pathway. Int Immunopharmacol. 142(112832)2024.PubMed/NCBI View Article : Google Scholar

15 

Cui H and Zhang Q: Dexmedetomidine ameliorates lipopolysaccharide-induced acute lung injury by inhibiting the PI3K/Akt/FoxO1 signaling pathway. J Anesth. 35:394–404. 2021.PubMed/NCBI View Article : Google Scholar

16 

Han J, Liu X and Wang L: Dexmedetomidine protects against acute lung injury in mice via the DUSP1/MAPK/NF-κB axis by inhibiting miR-152-3p. Pulm Pharmacol The: 102131, 2022 (Epub ahead of print).

17 

Xin P, Xu X, Deng C, Liu S, Wang Y, Zhou X, Ma H, Wei D and Sun S: The role of JAK/STAT signaling pathway and its inhibitors in diseases. Int Immunopharmacol. 80(106210)2020.PubMed/NCBI View Article : Google Scholar

18 

Keenan C, Albeituni S, Nichols KE and Hines M: JAK inhibitors in cytokine storm syndromes. Adv Exp Med Biol. 1448:583–600. 2024.PubMed/NCBI View Article : Google Scholar

19 

Al-Ani B, ShamsEldeen AM, Kamar SS, Haidara MA, Al-Hashem F, Alshahrani MY, Al-Hakami AM, Kader DHA and Maarouf A: Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology. Clin Exp Pharmacol Physiol. 49:483–491. 2022.PubMed/NCBI View Article : Google Scholar

20 

Song Z, Zhao X, Gao Y, Liu M, Hou M, Jin H and Cui Y: Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK/STAT signaling pathway in rats. J Trauma Acute Care Surg. 78:980–987. 2015.PubMed/NCBI View Article : Google Scholar

21 

Xue C, Yao Q, Gu X, Shi Q, Yuan X, Chu Q, Bao Z, Lu J and Li L: Evolving cognition of the JAK-STAT signaling pathway: Autoimmune disorders and cancer. Signal Transduct Target Ther. 8(204)2023.PubMed/NCBI View Article : Google Scholar

22 

Xu F, Wang S, Wang Y, Hu L and Zhu L: Inhibition of gp130 alleviates LPS-induced lung injury by attenuating apoptosis and inflammation through JAK1/STAT3 signaling pathway. Inflamm Res. 72:493–507. 2023.PubMed/NCBI View Article : Google Scholar

23 

Zhou JR, Liao Y, Cao LQ, Ma R, He Y, Li N, Zhu DP, Zhao XS, Huang XJ and Sun YQ: Interleukin 6 is significantly increased in severe pneumonia after allo-hematopoietic stem cell transplantation and might induce lung injury via IL-6/sIL-6R/JAK1/STAT3 pathway. J Infect Dis. 232:113–126. 2025.PubMed/NCBI View Article : Google Scholar

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

25 

Lin KC, Chang TM, Sun YS, Lin YR, Tang CH and Liu JF: CXCL8 drives MMP1 upregulation and promotes metastatic progression in oral cancer through CXCR1/2-mediated JAK1/STAT3 activation. Int J Biol Sci. 22:2285–2301. 2026.PubMed/NCBI View Article : Google Scholar

26 

Shan M, Zhang S, Luo Z, Deng S, Ran L, Zhou Q, Wan H, Ye J, Qian C, Fan X, et al: Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury. Cell Metab. 37:1750–1765.e7. 2025.PubMed/NCBI View Article : Google Scholar

27 

Zou X, Liu C, Huang Z, Xiang S, Li K, Yuan Y, Hao Y and Zhou F: Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells. Mol Biol Rep. 50:5667–5674. 2023.PubMed/NCBI View Article : Google Scholar

28 

Tu Y, Li X, Fu Y, Chen Y, Fang H, Li Y, Gu Y and Zhang J: Isocorydine ameliorates IL-6 expression in bone marrow-derived macrophages and acute lung injury induced by lipopolysaccharide. Int J Mol Sci. 24(4629)2023.PubMed/NCBI View Article : Google Scholar

29 

Jia J, Yuan Y, He Y, Wasti B, Duan W, Chen Z, Li D, Sun W, Zeng Q, Ma L, et al: Inhibition of METTL3 alleviated LPS-induced alveolar epithelial cell apoptosis and acute lung injury via restoring neprilysin expression. Life Sci. 333(122148)2023.PubMed/NCBI View Article : Google Scholar

30 

Wang JF, Wang YP, Xie J, Zhao ZZ, Gupta S, Guo Y, Jia SH, Parodo J, Marshall JC and Deng XM: Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. 138:806–810. 2021.PubMed/NCBI View Article : Google Scholar

31 

Kurdowska AK and Florence JM: Promoting neutrophil apoptosis to treat acute lung injury. Am J Respir Crit Care Med. 200:399–400. 2019.PubMed/NCBI View Article : Google Scholar

32 

Li X, Jamal M, Guo P, Jin Z, Zheng F, Song X, Zhan J and Wu H: Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways. Biomed Pharmacother. 118(109363)2019.PubMed/NCBI View Article : Google Scholar

33 

Liu L, Yuan Y, Zhou Y, Yao L, Li J and Chen F: The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice. Mol Immunol. 152:67–77. 2022.PubMed/NCBI View Article : Google Scholar

34 

Zhou X, Wang M, Sun M and Yao N: HSPB8 attenuates lipopolysaccharide-mediated acute lung injury in A549 cells by activating mitophagy. Mol Med Rep. 30(171)2024.PubMed/NCBI View Article : Google Scholar

35 

Li J, Chen Q, He X, Alam A, Ning J, Yi B, Lu K and Gu J: Dexmedetomidine attenuates lung apoptosis induced by renal ischemia-reperfusion injury through α2AR/PI3K/Akt pathway. J Transl Med. 16(78)2018.PubMed/NCBI View Article : Google Scholar

36 

Huang L, Du B, Cui X, Zhao H, Feng Y, Xu Z, Long J, Yuan J and You F: Nerelimomab alleviates capsaicin-induced acute lung injury by inhibiting TNF signaling and apoptosis. Pharmaceuticals (Basel). 17(1694)2024.PubMed/NCBI View Article : Google Scholar

37 

Yang J and Chen X: SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling. Immun Inflamm Dis. 11(e809)2023.PubMed/NCBI View Article : Google Scholar

38 

Sims NA: The JAK1/STAT3/SOCS3 axis in bone development, physiology, and pathology. Exp Mol Med. 52:1185–1197. 2020.PubMed/NCBI View Article : Google Scholar

39 

Traves PG, Murray B, Campigotto F, Galien R, Meng A and Di Paolo JA: JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib. Ann Rheum Dis. 80:865–875. 2021.PubMed/NCBI View Article : Google Scholar

40 

RECOVERY Collaborative Group. Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): A randomised, controlled, open-label, platform trial and updated meta-analysis. Lancet. 400:359–368. 2022.PubMed/NCBI View Article : Google Scholar

41 

Joshi K, Singh V, Chatterjee S, Khandelwal P, Nair R, Qureshi S, Siddh S and Nunia V: Assessment of lapachol's anti-inflammatory effectiveness in mitigating sepsis-induced acute lung injury. Fitoterapia. 180(106298)2025.PubMed/NCBI View Article : Google Scholar

42 

Zhang Z, Zhu Q, Wang S and Shi C: Epigallocatechin-3-gallate inhibits the formation of neutrophil extracellular traps and suppresses the migration and invasion of colon cancer cells by regulating STAT3/CXCL8 pathway. Mol Cell Biochem. 478:887–898. 2023.PubMed/NCBI View Article : Google Scholar

43 

Li W, Liu Q, Xiong W, Zhong X and Tian L: Decoding STAT3: A new frontier in understanding and treating hyperoxic lung injury. Front Immunol. 16(1657823)2025.PubMed/NCBI View Article : Google Scholar

44 

Kubra KT and Barabutis N: Ceapin-A7 potentiates lipopolysaccharide-induced endothelial injury. J Biochem Mol Toxicol. 37(e23460)2023.PubMed/NCBI View Article : Google Scholar

45 

Zhuo Y, Li D, Cui L, Li C, Zhang S, Zhang Q, Zhang L, Wang X and Yang L: Treatment with 3,4-dihydroxyphenylethyl alcohol glycoside ameliorates sepsis-induced ALI in mice by reducing inflammation and regulating M1 polarization. Biomed Pharmacother. 116(109012)2019.PubMed/NCBI View Article : Google Scholar

46 

Yang S, Zhou S, Wang W, Cao L, Xue T, Xu J, Lv K and Huang M: A novel STAT3 CCD inhibitor for suppressing macrophage activation and lipopolysaccharide-induced acute lung injury. Int Immunopharmacol. 143(113523)2024.PubMed/NCBI View Article : Google Scholar

47 

Xu S, Deng KQ, Lu C, Fu X, Zhu Q, Wan S, Zhang L, Huang Y, Nie L, Cai H, et al: Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects. Metabolism. 155(155832)2024.PubMed/NCBI View Article : Google Scholar

48 

Li R, Liang Q, Yang Q, Dai W, Xiao Y, Pan H, Zhang Z, Liu L and Li X: Hexahydrocurcumin from Zingiberis rhizoma attenuates lipopolysaccharide-induced acute pneumonia through JAK1/STAT3 signaling pathway. Phytomedicine. 122(155141)2024.PubMed/NCBI View Article : Google Scholar

49 

Yin J, Yu Z, Hou C, Peng Y, Xiao J and Jiang J: Protective effect of zuojin fang on lung injury induced by sepsis through downregulating the JAK1/STAT3 signaling pathway. Biomed Res Int. 2021(1419631)2021.PubMed/NCBI View Article : Google Scholar

50 

Zhang ZM, Li LZ, Li KH, An CY, Li YL, Li L and Wu GY: The effects of dexmedetomidine administered at various times on acute lung injury in rats. Eur Rev Med Pharmacol Sci. 25:2093–2098. 2021.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding X, Shi D, Wang J, Cai H and Yan Z: Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis. Exp Ther Med 31: 179, 2026.
APA
Ding, X., Shi, D., Wang, J., Cai, H., & Yan, Z. (2026). Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis. Experimental and Therapeutic Medicine, 31, 179. https://doi.org/10.3892/etm.2026.13174
MLA
Ding, X., Shi, D., Wang, J., Cai, H., Yan, Z."Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis". Experimental and Therapeutic Medicine 31.6 (2026): 179.
Chicago
Ding, X., Shi, D., Wang, J., Cai, H., Yan, Z."Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis". Experimental and Therapeutic Medicine 31, no. 6 (2026): 179. https://doi.org/10.3892/etm.2026.13174
Copy and paste a formatted citation
x
Spandidos Publications style
Ding X, Shi D, Wang J, Cai H and Yan Z: Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis. Exp Ther Med 31: 179, 2026.
APA
Ding, X., Shi, D., Wang, J., Cai, H., & Yan, Z. (2026). Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis. Experimental and Therapeutic Medicine, 31, 179. https://doi.org/10.3892/etm.2026.13174
MLA
Ding, X., Shi, D., Wang, J., Cai, H., Yan, Z."Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis". Experimental and Therapeutic Medicine 31.6 (2026): 179.
Chicago
Ding, X., Shi, D., Wang, J., Cai, H., Yan, Z."Dexmedetomidine alleviates acute lung injury in humans by modulating the JAK1‑STAT3 axis". Experimental and Therapeutic Medicine 31, no. 6 (2026): 179. https://doi.org/10.3892/etm.2026.13174
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team