Research progress of lactylation modification in tumors (Review)

Fang,Shi-Chao; Shi,Zhi-Zhou

doi:10.3892/etm.2026.13229

September-2026 Volume 32 Issue 3

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September-2026 Volume 32 Issue 3

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Review Open Access

Research progress of lactylation modification in tumors (Review)

Authors:
- Shi-Chao Fang
- Zhi-Zhou Shi
View Affiliations / Copyright

Affiliations: Laboratory of Molecular Neurobiology, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China

Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 233
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Published online on: July 6, 2026

https://doi.org/10.3892/etm.2026.13229
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Abstract

Lactic acid was once thought to be only a metabolic product of glycolysis. An increasing number of studies, however, have reported that lactic acid produced by glycolysis is a multifunctional signaling molecule that not only serves as an essential energy source, signaling molecule and immunomodulatory molecule but also controls metabolism, the immune response and intercellular communication. It has been discovered that lactylation is a posttranslational modification of proteins that regulates and creates an acidic tumor microenvironment, directly regulates gene expression and promotes the recruitment and management of immune signaling molecules, among other processes, to promote tumor survival and progression. The lactylation of histones and non‑histone proteins, which is regulated by different mechanisms, is a notable subject of current research on the tumor microenvironment and tumor progression. The present review covered the discovery of lactylation and the research advances on the role of lactylation in metabolism, immunity, metastasis and cell proliferation across different tumors. These findings open up the possibility for in‑depth investigation of the role of lactylation in tumors.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Research progress of lactylation modification in tumors (Review)

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Abstract

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