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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2026 Volume 32 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review)

  • Authors:
    • Jun Yin
    • Xiaojian Zhuo
    • Lihui Wen
    • Xianmin Wang
    • Tongyong Luo
    • Qingsong Wang

  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, West China Hospital Sichuan University, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Public Relations Department, West China Hospital Sichuan University, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Department of Pediatrics, West China Hospital Sichuan University, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Pediatric Cardiology Center, Sichuan Provincial Women's and Children's Hospital/ The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, Sichuan 610031, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 289
    |
    Published online on: September 2, 2026
       https://doi.org/10.3892/etm.2026.13284
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Abstract

Anti‑silencing function 1A (ASF1A) is an evolutionarily conserved histone H3/H4 chaperone that mediates nucleosome assembly, DNA replication and DNA damage repair. Beyond these canonical biological functions, aberrant ASF1A expression facilitates disease progression by triggering epigenetic dysregulation in multiple malignant tumors (including leukemia, breast, liver and gastrointestinal cancers) and non‑neoplastic disorders (such as atherosclerosis and embryonic developmental defects). Its context‑dependent biological effects are mediated via oncogenic signaling cascades and crosstalk between metabolism and epigenetics. Although preclinical studies have validated ASF1A as a promising prognostic biomarker and therapeutic target, relevant clinical trials supporting its clinical application remain absent. This review systematically summarizes the molecular features, pathogenic mechanisms and translational application potential of ASF1A.

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Copy and paste a formatted citation
Spandidos Publications style
Yin J, Zhuo X, Wen L, Wang X, Luo T and Wang Q: ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review). Exp Ther Med 32: 289, 2026.
APA
Yin, J., Zhuo, X., Wen, L., Wang, X., Luo, T., & Wang, Q. (2026). ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review). Experimental and Therapeutic Medicine, 32, 289. https://doi.org/10.3892/etm.2026.13284
MLA
Yin, J., Zhuo, X., Wen, L., Wang, X., Luo, T., Wang, Q."ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review)". Experimental and Therapeutic Medicine 32.4 (2026): 289.
Chicago
Yin, J., Zhuo, X., Wen, L., Wang, X., Luo, T., Wang, Q."ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review)". Experimental and Therapeutic Medicine 32, no. 4 (2026): 289. https://doi.org/10.3892/etm.2026.13284
Copy and paste a formatted citation
x
Spandidos Publications style
Yin J, Zhuo X, Wen L, Wang X, Luo T and Wang Q: ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review). Exp Ther Med 32: 289, 2026.
APA
Yin, J., Zhuo, X., Wen, L., Wang, X., Luo, T., & Wang, Q. (2026). ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review). Experimental and Therapeutic Medicine, 32, 289. https://doi.org/10.3892/etm.2026.13284
MLA
Yin, J., Zhuo, X., Wen, L., Wang, X., Luo, T., Wang, Q."ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review)". Experimental and Therapeutic Medicine 32.4 (2026): 289.
Chicago
Yin, J., Zhuo, X., Wen, L., Wang, X., Luo, T., Wang, Q."ASF1A: A versatile histone chaperone bridging chromatin dynamics, disease mechanisms and clinical potential (Review)". Experimental and Therapeutic Medicine 32, no. 4 (2026): 289. https://doi.org/10.3892/etm.2026.13284
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