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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January-2026 Volume 57 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

  • Authors:
    • Xunjie Jian
    • Chang Cheng
    • Wenjie Lu
    • Hui Peng
    • Diqi Yang

  • View Affiliations

    Affiliations: School of Tropical Agriculture and Forestry, Hainan University, Hainan, Haikou 570228, P.R. China
  • Published online on: November 3, 2025     https://doi.org/10.3892/ijmm.2025.5682
  • Article Number: 11
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Abstract

Histone lactylation, a novel epigenetic modification, has emerged as a critical mediator of various physiological and pathological processes. The present review elucidates the molecular mechanisms of lysine lactylation (Kla) and its influence on gene expression modulation. In addition, previous findings regarding the mechanisms of Kla and its impact on metabolic regulation, inflammation and tumorigenesis are summarized. Histone lactylation influences macrophage polarization, promotes tumor immune evasion, and affects osteoblast differentiation and embryonic development. While promising as a therapeutic target, research progress is currently hindered by methodological limitations in terms of lactylation quantification and manipulation. The current review not only summarizes fundamental insights into Kla‑mediated disease pathogenesis but also critically addresses existing knowledge gaps. By highlighting the dynamic interplay between lactylation and metabolic regulation, novel perspectives are provided on the biological importance of this posttranslational modification. Ultimately, the aim of this review is to identify innovative approaches for targeting lactylation‑mediated pathways in disease treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Jian X, Cheng C, Lu W, Peng H and Yang D: Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review). Int J Mol Med 57: 11, 2026.
APA
Jian, X., Cheng, C., Lu, W., Peng, H., & Yang, D. (2026). Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review). International Journal of Molecular Medicine, 57, 11. https://doi.org/10.3892/ijmm.2025.5682
MLA
Jian, X., Cheng, C., Lu, W., Peng, H., Yang, D."Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)". International Journal of Molecular Medicine 57.1 (2026): 11.
Chicago
Jian, X., Cheng, C., Lu, W., Peng, H., Yang, D."Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)". International Journal of Molecular Medicine 57, no. 1 (2026): 11. https://doi.org/10.3892/ijmm.2025.5682
Copy and paste a formatted citation
x
Spandidos Publications style
Jian X, Cheng C, Lu W, Peng H and Yang D: Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review). Int J Mol Med 57: 11, 2026.
APA
Jian, X., Cheng, C., Lu, W., Peng, H., & Yang, D. (2026). Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review). International Journal of Molecular Medicine, 57, 11. https://doi.org/10.3892/ijmm.2025.5682
MLA
Jian, X., Cheng, C., Lu, W., Peng, H., Yang, D."Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)". International Journal of Molecular Medicine 57.1 (2026): 11.
Chicago
Jian, X., Cheng, C., Lu, W., Peng, H., Yang, D."Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)". International Journal of Molecular Medicine 57, no. 1 (2026): 11. https://doi.org/10.3892/ijmm.2025.5682
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