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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September-2026 Volume 58 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

  • Authors:
    • Changzhong Qian
    • Zhenyu Zhang
    • Xian Wu
    • Huibo Ti
    • Junjie Wu
    • Zhengdong Yuan
    • Xia Li
    • Feng-Lai Yuan

  • View Affiliations / Copyright

    Affiliations: Institute of Integrated Chinese and Western Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214131, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 247
    |
    Published online on: July 6, 2026
       https://doi.org/10.3892/ijmm.2026.5918
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Abstract

Rheumatoid arthritis (RA) is an inflammatory, systematic and articular autoimmune disease characterized by progressive cartilage degradation and bone erosion, leading to irreversible joint deformity. Fibroblast growth factor receptor 1 (FGFR1) is a key mediator of RA‑associated bone loss. Within inflamed joints, FGFR1 expression is markedly upregulated in synovial fibroblasts, osteoclasts and chondrocytes. Ligand engagement drives receptor dimerization and kinase activation, activating PI3K/Akt, MAPK and STAT signaling cascades that amplify cytokine release, matrix metalloproteinase expression and osteoclastogenesis. These converging signals promote cartilage degradation and cortical bone erosion, fueling progressive deformity. Targeting FGFR1 markedly attenuates bone loss and disease severity in both murine and humanized models. The present review aimed to summarize the potential of FGFR1 as a tractable therapeutic node for RA bone destruction.

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Copy and paste a formatted citation
Spandidos Publications style
Qian C, Zhang Z, Wu X, Ti H, Wu J, Yuan Z, Li X and Yuan F: FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review). Int J Mol Med 58: 247, 2026.
APA
Qian, C., Zhang, Z., Wu, X., Ti, H., Wu, J., Yuan, Z. ... Yuan, F. (2026). FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review). International Journal of Molecular Medicine, 58, 247. https://doi.org/10.3892/ijmm.2026.5918
MLA
Qian, C., Zhang, Z., Wu, X., Ti, H., Wu, J., Yuan, Z., Li, X., Yuan, F."FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)". International Journal of Molecular Medicine 58.3 (2026): 247.
Chicago
Qian, C., Zhang, Z., Wu, X., Ti, H., Wu, J., Yuan, Z., Li, X., Yuan, F."FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)". International Journal of Molecular Medicine 58, no. 3 (2026): 247. https://doi.org/10.3892/ijmm.2026.5918
Copy and paste a formatted citation
x
Spandidos Publications style
Qian C, Zhang Z, Wu X, Ti H, Wu J, Yuan Z, Li X and Yuan F: FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review). Int J Mol Med 58: 247, 2026.
APA
Qian, C., Zhang, Z., Wu, X., Ti, H., Wu, J., Yuan, Z. ... Yuan, F. (2026). FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review). International Journal of Molecular Medicine, 58, 247. https://doi.org/10.3892/ijmm.2026.5918
MLA
Qian, C., Zhang, Z., Wu, X., Ti, H., Wu, J., Yuan, Z., Li, X., Yuan, F."FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)". International Journal of Molecular Medicine 58.3 (2026): 247.
Chicago
Qian, C., Zhang, Z., Wu, X., Ti, H., Wu, J., Yuan, Z., Li, X., Yuan, F."FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)". International Journal of Molecular Medicine 58, no. 3 (2026): 247. https://doi.org/10.3892/ijmm.2026.5918
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