Vascular retardation in dormant growth-stunted malignant melanomas.

  • Authors:
    • C Piérard-Franchimont
    • F Henry
    • O Heymans
    • G E Piérard
  • View Affiliations

  • Published online on: October 1, 1999     https://doi.org/10.3892/ijmm.4.4.403
  • Pages: 403-409
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Progression and metastatic spread of primary cutaneous melanoma (PCM) is largely predicted by the thickness of the primary tumor. However, the accretive or proliferative pattern of growth of PCM is another aspect that might affect the prognosis. We retrieved from our histopathological files 11 superficial spreading PCM which had been documented to show an almost stable size for at least 3 years before excision. The area of the PCM at the skin surface had been measured by planimetry on the excision specimens. Histological sections were used to measure the maximum thickness of the neoplasms. A PCM volume estimate was derived by multiplying the surface area by the thickness of the tumors. In addition, the vessel area was determined beneath and outside the PCM lateral margins on Ulex europaeus agglutinin-1-stained sections using computer-assisted image analysis. Peritumoral vascularity was significantly more developed than at distance of the neoplasms. A significant negative exponential correlation was yielded between the peritumoral vascularity and the PCM volume estimate. Such vascular eclipse might be the cause of clinical PCM dormancy. However, other possible independent mechanisms are not ruled out by the present study.

Related Articles

Journal Cover

Oct 1999
Volume 4 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Piérard-Franchimont C, Henry F, Heymans O and Piérard G: Vascular retardation in dormant growth-stunted malignant melanomas.. Int J Mol Med 4: 403-409, 1999
APA
Piérard-Franchimont, C., Henry, F., Heymans, O., & Piérard, G. (1999). Vascular retardation in dormant growth-stunted malignant melanomas.. International Journal of Molecular Medicine, 4, 403-409. https://doi.org/10.3892/ijmm.4.4.403
MLA
Piérard-Franchimont, C., Henry, F., Heymans, O., Piérard, G."Vascular retardation in dormant growth-stunted malignant melanomas.". International Journal of Molecular Medicine 4.4 (1999): 403-409.
Chicago
Piérard-Franchimont, C., Henry, F., Heymans, O., Piérard, G."Vascular retardation in dormant growth-stunted malignant melanomas.". International Journal of Molecular Medicine 4, no. 4 (1999): 403-409. https://doi.org/10.3892/ijmm.4.4.403