Identification of a novel β-chemokine, MEC, down-regulated in primary breast tumors

Mickanin,Craig S.; Bhatia,Umesh; Labow,Mark

doi:10.3892/ijo.18.5.939

May 2001 Volume 18 Issue 5

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May 2001 Volume 18 Issue 5

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Article

Identification of a novel β-chemokine, MEC, down-regulated in primary breast tumors

Authors:
- Craig S. Mickanin
- Umesh Bhatia
- Mark Labow
View Affiliations / Copyright

Affiliations: Department of Functional Genomics, Novartis Pharmaceuticals Corporation, Summit, NJ 07901, USA
Pages: 939-944
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Published online on: May 1, 2001

https://doi.org/10.3892/ijo.18.5.939
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Abstract

Chemokines represent a family of low molecular weight secreted proteins that primarily function in the activation and migration of leukocytes. A number of additional functions of chemokines have also been identified including growth of tumor cells, angiogenesis and development. An iterative search for new chemokines has identified a cDNA that encodes a new member of the CC(β) chemokine family. The gene has been named MEC, for mammary enriched chemokine. MEC expression was found at high levels in many mammary gland samples and was also detected at lower levels in several other epithelial-enriched tissues, such as salivary gland, colon, and prostate. Northern blot analysis demonstrates that MEC expression was highly reduced or eliminated in a majority of human breast tumors as compared to normal adjacent tissue. In situ hybridization demonstrates that MEC was abundantly expressed in normal mammary ductal epithelium, but expression was absent or reduced in various mammary tumor types of epithelial origin. These observations suggest that MEC may be useful as a diagnostic tool in oncology, and may play a role in regulating mammary carcinogenesis. The absence of MEC may also contribute to the host's immune response to tumors.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Identification of a novel β-chemokine, MEC, down-regulated in primary breast tumors

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Abstract

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