Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo

  • Authors:
    • Mohammad Akbar Hossain
    • Dong Hwan Kim
    • Jung Yoon Jang
    • Yong Jung Kang
    • Jeong-Hyun Yoon
    • Jeon-Ok Moon
    • Hae Young Chung
    • Gi-Young Kim
    • Yung Hyun Choi
    • Bryan L. Copple
    • Nam Deuk Kim
  • View Affiliations

  • Published online on: February 7, 2012     https://doi.org/10.3892/ijo.2012.1359
  • Pages: 1636-1642
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Abstract

Combined therapy with multiple drugs is a common practice in the treatment of cancer, which can achieve better therapeutic effects than a single drug, and can reduce the side effects as well as drug resistance. This study aimed to determine whether aspirin (ASA) shows synergism with doxorubicin (DOX) in HepG2 human hepatocellular carcinoma cells in vitro and in a HepG2 cell xenograft model in BALB/c nude mice. When treated in combination, DOX (0.25 nmol/ml) and ASA (5 µmol/ml) produced strong synergy in growth inhibition, cell cycle arrest and importantly, apoptosis in vitro in comparison to single treatments. Moreover, ASA (100 mg/kg/day orally) and DOX (1.2 mg/kg biweekly ip) induced synergistic antitumor activity in the HepG2 cell xenograft model in nude mice. Therefore, the combination of ASA and DOX could be used as a novel combination regimen which provides a strong anticancer synergy in the treatment of hepatocellular carcinoma.

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May 2012
Volume 40 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Hossain MA, Kim DH, Jang JY, Kang YJ, Yoon J, Moon J, Chung HY, Kim G, Choi YH, Copple BL, Copple BL, et al: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. Int J Oncol 40: 1636-1642, 2012
APA
Hossain, M.A., Kim, D.H., Jang, J.Y., Kang, Y.J., Yoon, J., Moon, J. ... Kim, N.D. (2012). Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. International Journal of Oncology, 40, 1636-1642. https://doi.org/10.3892/ijo.2012.1359
MLA
Hossain, M. A., Kim, D. H., Jang, J. Y., Kang, Y. J., Yoon, J., Moon, J., Chung, H. Y., Kim, G., Choi, Y. H., Copple, B. L., Kim, N. D."Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo". International Journal of Oncology 40.5 (2012): 1636-1642.
Chicago
Hossain, M. A., Kim, D. H., Jang, J. Y., Kang, Y. J., Yoon, J., Moon, J., Chung, H. Y., Kim, G., Choi, Y. H., Copple, B. L., Kim, N. D."Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo". International Journal of Oncology 40, no. 5 (2012): 1636-1642. https://doi.org/10.3892/ijo.2012.1359