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Article

SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma

  • Authors:
    • Tatsuya Kato
    • Daiyoon Lee
    • Licun Wu
    • Priya Patel
    • Ahn Jin Young
    • Hironobu Wada
    • Hsin-Pei Hu
    • Hideki Ujiie
    • Mitsuhito Kaji
    • Satoshi Kano
    • Shinichi Matsuge
    • Hiromitsu Domen
    • Hiromi Kanno
    • Yutaka Hatanaka
    • Kanako C. Hatanaka
    • Kichizo Kaga
    • Yoshiro Matsui
    • Yoshihiro Matsuno
    • Marc De Perrot
    • Kazuhiro Yasufuku
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Canada, Department of Thoracic Surgery, Sapporo Minami-sanjo Hospital, Sapporo, Japan, Department of Pathology, Kinikyo-Chuo Hospital, Sapporo, Japan, Department of Surgery, Kinikyo-Chuo Hospital, Sapporo, Japan, Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan, Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan
  • Pages: 2411-2420
    |
    Published online on: November 10, 2016
       https://doi.org/10.3892/ijo.2016.3765
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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive type of cancer of the thoracic cavity commonly associated with asbestos exposure and a high mortality rate. There is a need for new molecular targets for the development of more effective therapies for MPM. Using quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and an RNA interference-based screening, we examined the SORORIN gene as potential therapeutic targets for MPM in addition to the PLK1 gene, which is known for kinase of SORORIN. Following in vitro investigation of the effects of target silencing on MPM cells, cell cycle analyses were performed. SORORIN expression was analyzed immunohistochemically using a total of 53 MPM samples on tissue microarray. SORORIN was found to be overexpressed in the majority of clinical MPM samples and human MPM cell lines as determined by qRT-PCR. Gene suppression of each SORORIN and PLK1 led to growth inhibition in MPM cell lines. Knockdown of SORORIN showed an increased number of G2M-phase population and a larger nuclear size, suggesting mitotic arrest. High expression of SORORIN (SORORIN-H) was found in 50.9% of all the MPM cases, and there is a tendency towards poorer prognosis for the SORORIN-H group but the difference is not significant. Suppression of SORORIN with PLK1 inhibitor BI 6727 showed a combinational growth suppressive effect on MPM cell growth. Given high-dose PLK1 inhibitor induced drug-related adverse effects in several clinical trials, our results suggest inhibition SORORIN-PLK1 axis may hold promise for the treatment of MPMs.
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1 

Yang H, Testa JR and Carbone M: Mesothelioma epidemiology, carcinogenesis, and pathogenesis. Curr Treat Options Oncol. 9:147–157. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Carbone M, Kratzke RA and Testa JR: The pathogenesis of mesothelioma. Semin Oncol. 29:2–17. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Travis WD, Brambilla E, Burke AP, Marx A and Nicholson AG: WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart. 4th edition. 7. WHO Press; 2015

4 

Robinson BW and Lake RA: Advances in malignant mesothelioma. N Engl J Med. 353:1591–1603. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Robinson BW, Musk AW and Lake RA: Malignant mesothelioma. Lancet. 366:397–408. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Becklake MR, Bagatin E and Neder JA: Asbestos-related diseases of the lungs and pleura: Uses, trends and management over the last century. Int J Tuberc Lung Dis. 11:356–369. 2007.PubMed/NCBI

7 

Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, Gatzemeier U, Boyer M, Emri S, Manegold C, et al: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 21:2636–2644. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Zucali PA, De Vincenzo F, Simonelli M and Santoro A: Future developments in the management of malignant pleural mesothelioma. Expert Rev Anticancer Ther. 9:453–467. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Cho BC, Feld R, Leighl N, Opitz I, Anraku M, Tsao MS, Hwang DM, Hope A and de Perrot M: A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: The ‘SMART’ approach for resectable malignant pleural mesothelioma. J Thorac Oncol. 9:397–402. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kato T, Wada H, Patel P, Hu HP, Lee D, Ujiie H, Hirohashi K, Nakajima T, Sato M, Kaji M, et al: Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients. Lung Cancer. 92:53–61. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu HP, Ujiie H, Kaji M, Kano S, et al: Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol. 49:448–456. 2016.PubMed/NCBI

12 

Zhang N, Panigrahi AK, Mao Q and Pati D: Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem. 286:41826–41837. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Union for International Cancer Control (UICC). TNM Classification of Malignant Tumours. 7th edition. Wiley-Blackwell; 2009

14 

Rizzardi AE, Johnson AT, Vogel RI, Pambuccian SE, Henriksen J, Skubitz AP, Metzger GJ and Schmechel SC: Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring. Diagn Pathol. 7:422012. View Article : Google Scholar : PubMed/NCBI

15 

Nagashio R, Sato Y, Jiang SX, Ryuge S, Kodera Y, Maeda T and Nakajima T: Detection of tumor-specific autoantibodies in sera of patients with lung cancer. Lung Cancer. 62:364–373. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Nagashio R, Sato Y, Matsumoto T, Kageyama T, Satoh Y, Shinichiro R, Masuda N, Goshima N, Jiang SX and Okayasu I: Expression of RACK1 is a novel biomarker in pulmonary adenocarcinomas. Lung Cancer. 69:54–59. 2010. View Article : Google Scholar

17 

Kawata E, Ashihara E, Nakagawa Y, Kiuchi T, Ogura M, Yao H, Sakai K, Tanaka R, Nagao R, Yokota A, et al: A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro. Cancer Lett. 294:245–253. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Linton A, Cheng YY, Griggs K, Kirschner MB, Gattani S, Srikaran S, Chuan-Hao Kao S, McCaughan BC, Klebe S, van Zandwijk N, et al: An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. Br J Cancer. 110:510–519. 2014. View Article : Google Scholar :

19 

Rankin S, Ayad NG and Kirschner MW: Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 18:185–200. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Schmitz J, Watrin E, Lénárt P, Mechtler K and Peters JM: Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol. 17:630–636. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Valcárcel J and Malumbres M: Splicing together sister chromatids. EMBO J. 33:2601–2603. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Zhang N and Pati D: Sororin is a master regulator of sister chromatid cohesion and separation. Cell Cycle. 11:2073–2083. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y and Daigo Y: Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Cancer Res. 70:5337–5347. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Bonnal S, Vigevani L and Valcárcel J: The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Discov. 11:847–859. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Cooper TA, Wan L and Dreyfuss G: RNA and disease. Cell. 136:777–793. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Losada A: Cohesin in cancer: Chromosome segregation and beyond. Nat Rev Cancer. 14:389–393. 2014. View Article : Google Scholar : PubMed/NCBI

27 

van de Weerdt BC and Medema RH: Polo-like kinases: A team in control of the division. Cell Cycle. 5:853–864. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Barr FA, Silljé HH and Nigg EA: Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol. 5:429–440. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Takahashi T, Sano B, Nagata T, Kato H, Sugiyama Y, Kunieda K, Kimura M, Okano Y and Saji S: Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers. Cancer Sci. 94:148–152. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Knecht R, Elez R, Oechler M, Solbach C, von Ilberg C and Strebhardt K: Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res. 59:2794–2797. 1999.PubMed/NCBI

31 

Weichert W, Denkert C, Schmidt M, Gekeler V, Wolf G, Köbel M, Dietel M and Hauptmann S: Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Br J Cancer. 90:815–821. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Wolf G, Elez R, Doermer A, Holtrich U, Ackermann H, Stutte HJ, Altmannsberger HM, Rübsamen-Waigmann H and Strebhardt K: Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer. Oncogene. 14:543–549. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Kawata E, Ashihara E and Maekawa T: RNA interference against polo-like kinase-1 in advanced non-small cell lung cancers. J Clin Bioinforma. 1:62011. View Article : Google Scholar : PubMed/NCBI

34 

Sebastian M, Reck M, Waller CF, Kortsik C, Frickhofen N, Schuler M, Fritsch H, Gaschler-Markefski B, Hanft G, Munzert G, et al: The efficacy and safety of BI 2536, a novel Plk-1 inhibitor, in patients with stage IIIB/IV non-small cell lung cancer who had relapsed after, or failed, chemotherapy: Results from an open-label, randomized phase II clinical trial. J Thorac Oncol. 5:1060–1067. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Ellis PM, Chu QS, Leighl N, Laurie SA, Fritsch H, Gaschler-Markefski B, Gyorffy S and Munzert G: A phase I open-label dose-escalation study of intravenous BI 2536 together with pemetrexed in previously treated patients with non-small-cell lung cancer. Clin Lung Cancer. 14:19–27. 2013. View Article : Google Scholar

36 

Liu X: Targeting Polo-Like Kinases: A Promising Therapeutic approach for cancer treatment. Transl Oncol. 8:185–195. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Schöffski P, Awada A, Dumez H, Gil T, Bartholomeus S, Wolter P, Taton M, Fritsch H, Glomb P and Munzert G: A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours. Eur J Cancer. 48:179–186. 2012. View Article : Google Scholar

38 

Stadler WM, Vaughn DJ, Sonpavde G, Vogelzang NJ, Tagawa ST, Petrylak DP, Rosen P, Lin CC, Mahoney J, Modi S, et al: An open-label, single-arm, phase 2 trial of the Polo-like kinase inhibitor volasertib (BI 6727) in patients with locally advanced or metastatic urothelial cancer. Cancer. 120:976–982. 2014. View Article : Google Scholar

39 

Awada A, Dumez H, Aftimos PG, Costermans J, Bartholomeus S, Forceville K, Berghmans T, Meeus MA, Cescutti J, Munzert G, et al: Phase I trial of volasertib, a Polo-like kinase inhibitor, plus platinum agents in solid tumors: Safety, pharmacokinetics and activity. Invest New Drugs. 33:611–620. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Machiels JP, Peeters M, Herremans C, Surmont V, Specenier P, De Smet M, Pilz K, Strelkowa N, Liu D and Rottey S: A phase I study of volasertib combined with afatinib, in advanced solid tumors. Cancer Chemother Pharmacol. 76:843–851. 2015. View Article : Google Scholar : PubMed/NCBI

41 

de Braud F, Cascinu S, Spitaleri G, Pilz K, Clementi L, Liu D, Sikken P and De Pas T: A phase I, dose-escalation study of volasertib combined with nintedanib in advanced solid tumors. Ann Oncol. 26:2341–2346. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu H, Ujiie H, Kaji M, Kano S, Kano S, et al: SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol 49: 2411-2420, 2016.
APA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A.J., Wada, H. ... Yasufuku, K. (2016). SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma. International Journal of Oncology, 49, 2411-2420. https://doi.org/10.3892/ijo.2016.3765
MLA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Kaga, K., Matsui, Y., Matsuno, Y., De Perrot, M., Yasufuku, K."SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49.6 (2016): 2411-2420.
Chicago
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Kaga, K., Matsui, Y., Matsuno, Y., De Perrot, M., Yasufuku, K."SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49, no. 6 (2016): 2411-2420. https://doi.org/10.3892/ijo.2016.3765
Copy and paste a formatted citation
x
Spandidos Publications style
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu H, Ujiie H, Kaji M, Kano S, Kano S, et al: SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol 49: 2411-2420, 2016.
APA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A.J., Wada, H. ... Yasufuku, K. (2016). SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma. International Journal of Oncology, 49, 2411-2420. https://doi.org/10.3892/ijo.2016.3765
MLA
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Kaga, K., Matsui, Y., Matsuno, Y., De Perrot, M., Yasufuku, K."SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49.6 (2016): 2411-2420.
Chicago
Kato, T., Lee, D., Wu, L., Patel, P., Young, A. J., Wada, H., Hu, H., Ujiie, H., Kaji, M., Kano, S., Matsuge, S., Domen, H., Kanno, H., Hatanaka, Y., Hatanaka, K. C., Kaga, K., Matsui, Y., Matsuno, Y., De Perrot, M., Yasufuku, K."SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma". International Journal of Oncology 49, no. 6 (2016): 2411-2420. https://doi.org/10.3892/ijo.2016.3765
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