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Article Open Access

lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster

  • Authors:
    • Guoli Shao
    • Mengchuan Wang
    • Xulong Fan
    • Lin Zhong
    • Zixiang Wang
    • Pusheng Zhang
    • Shufeng Ji
  • View Affiliations / Copyright

    Affiliations: Specialized Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China, Maternity and Children's Healthcare Hospital of Foshan, Foshan, Guangdong 52800, P.R. China
    Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1665-1675
    |
    Published online on: February 28, 2019
       https://doi.org/10.3892/ijo.2019.4734
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Abstract

Accumulating evidence has demonstrated that long non‑coding RNAs (lncRNAs) play important roles in the pathogenesis and development of diverse types of human disorders. Cancer susceptibility candidate 9 (CASC9), a gene encoding a lncRNA, has frequently been reported to be dysregulated and has been implicated in multiple types of human malignancies. However, the biological role of lncRNA CASC9 in breast cancer (BC) remains largely unknown. The present study aimed to investigate the role of lncRNA CASC9 in BC and to elucidate the potential molecular mechanisms involved. In the present study, lncRNA CASC9 was found to be significantly upregulated in both BC tissues and cell lines. Furthermore, functional analyses revealed that lncRNA CASC9 accelerated BC cell proliferation, promoted cell cycle progression and suppressed cell apoptosis. Moreover, mechanical experiments demonstrated that lncRNA CASC9 positively regulated checkpoint kinase 1 (CHK1) by competitively binding to the miR‑195/497 cluster in BC cells. Additionally, the knockdown of lncRNA CASC9 was observed to suppress breast tumor growth in vivo. Taken together, the results of this study indicate that lncRNA CASC9 plays an oncogenic role in BC through sponging the miR‑195/497 cluster, and that lncRNA CASC9 may be used as a novel therapeutic target and as a potential diagnostic marker for BC.
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1 

Hall IJ, Rim SH, Johnson-Turbes CA, Vanderpool R and Kamalu NN: The African American Women and Mass Media campaign: A CDC breast cancer screening project. J Womens Health (Larchmt). 21:1107–1113. 2012. View Article : Google Scholar

2 

Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, et al: Breast cancer metastasis: Challenges and opportunities. Cancer Res. 69:4951–4953. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Ursini-Siegel J and Muller WJ: The ShcA adaptor protein is a critical regulator of breast cancer progression. Cell Cycle. 7:1936–1943. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar

6 

Lytle GH: Immunotherapy of breast cancer: A review of the development of cell-specific therapy. Semin Surg Oncol. 7:211–216. 1991. View Article : Google Scholar : PubMed/NCBI

7 

Guerrero-Zotano A, Mayer IA and Arteaga CL: PI3K/AKT/mTOR: Role in breast cancer progression, drug resistance, and treatment. Cancer Metastasis Rev. 35:515–524. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Jain S, Thakkar N, Chhatai J, Pal Bhadra M and Bhadra U: Long non-coding RNA: Functional agent for disease traits. RNA Biol. 14:522–535. 2017. View Article : Google Scholar :

9 

Jin G, Sun J, Isaacs SD, Wiley KE, Kim ST, Chu LW, Zhang Z, Zhao H, Zheng SL, Isaacs WB, et al: Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis. 32:1655–1659. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Zhao J, Liu Y, Zhang W, Zhou Z, Wu J, Cui P, Zhang Y and Huang G: Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer. Cell Cycle. 14:3112–3123. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Shen Y, Katsaros D, Loo LW, Hernandez BY, Chong C, Canuto EM, Biglia N, Lu L, Risch H, Chu WM, et al: Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. Oncotarget. 6:8579–8592. 2015.PubMed/NCBI

12 

Lu W, Zhang H, Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H, et al: Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. Mol Cancer. 16:118–131. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, Fan S, Shi L, Li X, Zhang P, et al: Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol. 44:545–554. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Weiss M, Plass C and Gerhauser C: Role of lncRNAs in prostate cancer development and progression. Biol Chem. 395:1275–1290. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Cui Y, Yi L, Zhao JZ and Jiang YG: Long noncoding RNA HOXA11-AS functions as miRNA sponge to promote the glioma tumorigenesis through targeting miR-140-5p. DNA Cell Biol. 36:822–828. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Wu XS, Wang F, Li HF, Hu YP, Jiang L, Zhang F, Li ML, Wang XA, Jin YP, Zhang YJ, et al: LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. EMBO Rep. 18:1837–1853. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Pan Z, Mao W, Bao Y, Zhang M, Su X and Xu X: The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer. Cancer Med. 5:2442–2447. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Shang C, Sun L, Zhang J, Zhao B, Chen X, Xu H and Huang B: Silence of cancer susceptibility candidate 9 inhibits gastric cancer and reverses chemoresistance. Oncotarget. 8:15393–15398. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Wu Y, Hu L, Liang Y, Li J, Wang K, Chen X, Meng H, Guan X, Yang K and Bai Y: Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2. Mol Cancer. 16:150–162. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Su X, Li G and Liu W: The Long Noncoding RNA Cancer Susceptibility Candidate 9 Promotes Nasopharyngeal Carcinogenesis via Stabilizing HIF1α. DNA Cell Biol. 36:394–400. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Guo ST, Jiang CC, Wang GP, Li YP, Wang CY, Guo XY, Yang RH, Feng Y, Wang FH, Tseng HY, et al: MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. Oncogene. 32:1910–1920. 2013. View Article : Google Scholar :

22 

Grünhagen J, Bhushan R, Degenkolbe E, Jäger M, Knaus P, Mundlos S, Robinson PN and Ott CE: MiR-497~195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling. J Bone Miner Res. 30:796–808. 2015. View Article : Google Scholar

23 

Sato T, Yamamoto T and Sehara-Fujisawa A: miR-195/497 induce postnatal quiescence of skeletal muscle stem cells. Nat Commun. 5:45972014. View Article : Google Scholar : PubMed/NCBI

24 

Wei W, Zhang WY, Bai JB, Zhang HX, Zhao YY, Li XY and Zhao SH: The NF-κB-modulated microRNAs miR-195 and miR-497 inhibit myoblast proliferation by targeting Igf1r, Insr and cyclin genes. J Cell Sci. 129:39–50. 2016. View Article : Google Scholar

25 

Furuta M, Kozaki K, Tanimoto K, Tanaka S, Arii S, Shimamura T, Niida A, Miyano S and Inazawa J: The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One. 8:e601552013. View Article : Google Scholar : PubMed/NCBI

26 

Itesako T, Seki N, Yoshino H, Chiyomaru T, Yamasaki T, Hidaka H, Yonezawa T, Nohata N, Kinoshita T, Nakagawa M, et al: The microRNA expression signature of bladder cancer by deep sequencing: The functional significance of the miR-195/497 cluster. PLoS One. 9:e843112014. View Article : Google Scholar : PubMed/NCBI

27 

Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, et al: Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clin Cancer Res. 17:1722–1730. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar

29 

Shao Y, Ye M, Li Q, Sun W, Ye G, Zhang X, Yang Y, Xiao B and Guo J: LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer. Oncotarget. 7:37812–37824. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Yu X, Mi L, Dong J and Zou J: Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a 'sponge' against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells. BMC Cancer. 17:7162017. View Article : Google Scholar

31 

Xie Y, Wei RR, Huang GL, Zhang MY, Yuan YF and Wang HY: Checkpoint kinase 1 is negatively regulated by miR-497 in hepa-tocellular carcinoma. Med Oncol. 31:844–848. 2014. View Article : Google Scholar

32 

Konecny GE: Impact of molecular breast cancer portraits on new treatment strategies for gynecologic malignancies. Curr Opin Obstet Gynecol. 25:38–39. 2013. View Article : Google Scholar

33 

Kumi-Diaka J, Hassanhi M, Brown J, Merchant K, Garcia C and Jimenez W: CytoregR inhibits growth and proliferation of human adenocarcinoma cells via induction of apoptosis. J Carcinog. 5:1–8. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Prasad R, Vaid M and Katiyar SK: Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway. PLoS One. 7:e430642012. View Article : Google Scholar : PubMed/NCBI

35 

Atmaca H, Özkan AN and Zora M: Novel ferrocenyl pyrazoles inhibit breast cancer cell viability via induction of apoptosis and inhibition of PI3K/Akt and ERK1/2 signaling. Chem Biol Interact. 263:28–35. 2017. View Article : Google Scholar

36 

Marrone AK, Beland FA and Pogribny IP: Noncoding RNA response to xenobiotic exposure: An indicator of toxicity and carcinogenicity. Expert Opin Drug Metab Toxicol. 10:1409–1422. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Yang S, Ning Q, Zhang G, Sun H, Wang Z and Li Y: Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma. Oncotarget. 7:85728–85740. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Amer M, Elhefnawi M, El-Ahwany E, Awad AF, Gawad NA, Zada S and Tawab FM: Hsa-miR-195 targets PCMT1 in hepa-tocellular carcinoma that increases tumor life span. Tumour Biol. 35:11301–11309. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Yan JJ, Zhang YN, Liao JZ, Ke KP, Chang Y, Li PY, Wang M, Lin JS and He XX: MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget. 6:29527–29542. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Xu J, Wang T, Cao Z, Huang H, Li J, Liu W, Liu S, You L, Zhou L, Zhang T, et al: MiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosis. Oncotarget. 5:6983–6993. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Wang S, Mo Y, Midorikawa K, Zhang Z, Huang G, Ma N, Zhao W, Hiraku Y, Oikawa S and Murata M: The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L. Oncotarget. 6:35893–35907. 2015.PubMed/NCBI

42 

Zhao H and Piwnica-Worms H: ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 21:4129–4139. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, et al: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14:1448–1459. 2000.PubMed/NCBI

44 

Schmitt E, Boutros R, Froment C, Monsarrat B, Ducommun B and Dozier C: CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. J Cell Sci. 119:4269–4275. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Bryant C, Scriven K and Massey AJ: Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells. Mol Cancer. 13:147–158. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Parsels LA, Morgan MA, Tanska DM, Parsels JD, Palmer BD, Booth RJ, Denny WA, Canman CE, Kraker AJ, Lawrence TS, et al: Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. Mol Cancer Ther. 8:45–54. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Grabauskiene S, Bergeron EJ, Chen G, Thomas DG, Giordano TJ, Beer DG, Morgan MA and Reddy RM: Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer. J Surg Res. 187:6–13. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Itamochi H, Nishimura M, Oumi N, Kato M, Oishi T, Shimada M, Sato S, Naniwa J, Sato S, Kudoh A, et al: Checkpoint kinase inhibitor AZD7762 overcomes cisplatin resistance in clear cell carcinoma of the ovary. Int J Gynecol Cancer. 24:61–69. 2014. View Article : Google Scholar

49 

Cole KA, Huggins J, Laquaglia M, Hulderman CE, Russell MR, Bosse K, Diskin SJ, Attiyeh EF, Sennett R, Norris G, et al: RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci USA. 108:3336–3341. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shao G, Wang M, Fan X, Zhong L, Wang Z, Zhang P and Ji S: lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster. Int J Oncol 54: 1665-1675, 2019.
APA
Shao, G., Wang, M., Fan, X., Zhong, L., Wang, Z., Zhang, P., & Ji, S. (2019). lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster. International Journal of Oncology, 54, 1665-1675. https://doi.org/10.3892/ijo.2019.4734
MLA
Shao, G., Wang, M., Fan, X., Zhong, L., Wang, Z., Zhang, P., Ji, S."lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster". International Journal of Oncology 54.5 (2019): 1665-1675.
Chicago
Shao, G., Wang, M., Fan, X., Zhong, L., Wang, Z., Zhang, P., Ji, S."lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster". International Journal of Oncology 54, no. 5 (2019): 1665-1675. https://doi.org/10.3892/ijo.2019.4734
Copy and paste a formatted citation
x
Spandidos Publications style
Shao G, Wang M, Fan X, Zhong L, Wang Z, Zhang P and Ji S: lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster. Int J Oncol 54: 1665-1675, 2019.
APA
Shao, G., Wang, M., Fan, X., Zhong, L., Wang, Z., Zhang, P., & Ji, S. (2019). lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster. International Journal of Oncology, 54, 1665-1675. https://doi.org/10.3892/ijo.2019.4734
MLA
Shao, G., Wang, M., Fan, X., Zhong, L., Wang, Z., Zhang, P., Ji, S."lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster". International Journal of Oncology 54.5 (2019): 1665-1675.
Chicago
Shao, G., Wang, M., Fan, X., Zhong, L., Wang, Z., Zhang, P., Ji, S."lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster". International Journal of Oncology 54, no. 5 (2019): 1665-1675. https://doi.org/10.3892/ijo.2019.4734
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