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Case Report Open Access

Secretory carcinoma in the parotid gland: A case report

  • Authors:
    • Misaki Hayashi
    • Nobuyuki Bandoh
    • Takashi Goto
    • Shuto Hayashi
    • Ryota Arima
    • Koki Nakamuta
    • Tomomi Isochi‑Yamaguchi
    • Shogo Baba
    • Yasutaka Kato
    • Miki Takahara
    • Hidehiro Takei
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido 080‑0833, Japan, Department of Pathology and Genetics, Hokuto Hospital, Obihiro, Hokkaido 080‑0833, Japan, Department of Otolaryngology‑Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Hokkaido 078‑8510, Japan, Department of Pathology and Laboratory Medicine, University of Texas Health‑McGovern Medical School, Houston, TX 77030, USA
    Copyright: © Hayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 47
    |
    Published online on: May 7, 2026
       https://doi.org/10.3892/mco.2026.2956
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Abstract

Secretory carcinoma (SC) is a rare salivary gland neoplasm characterized by the ETV6::NTRK3 gene fusion, and it has been recognized as a distinct entity in the World Health Organization Classification of Head and Neck Tumors since 2017. Case 1 involved a 21‑year‑old Japanese man who presented with a 1‑year history of a slow‑growing, painless mass in the right parotid gland. Ultrasonography and magnetic resonance imaging demonstrated a well‑circumscribed, homogeneous tumor measuring 16x12x10 mm. The patient underwent superficial parotidectomy. Case 2 involved a 79‑year‑old Japanese man who noticed a mass in the right parotid region 3 weeks before presentation. Imaging studies revealed a tumor with irregular margins and heterogeneous internal features, measuring 21x16x15 mm. The patient underwent total parotidectomy with selective neck dissection. Histological examination revealed features consistent with SC in both cases. Immunohistochemically, the tumor cells were positive for S‑100 protein, mammaglobin and cytokeratin 7. The diagnosis was further supported by detection of the ETV6::NTRK3 gene fusion using reverse transcription‑polymerase chain reaction and Sanger sequencing. Both patients received postoperative radiotherapy at a total dose of 60 Gy. No evidence of local recurrence or distant metastasis has been observed during the follow‑up period of 7 years in case 1 and 3 years in case 2.
View Figures

Figure 1

Imaging and histological findings of
case 1. (A) Ultrasonography revealed a well-circumscribed,
homogeneous, isoechoic mass adjacent to a tiny cyst with posterior
acoustic enhancement, measuring 16x12x10 mm. MRI revealed a solid
mass in the right parotid gland, showing (B) low signal intensity
on T1-weighted imaging and (C) high signal intensity on T2-weighted
imaging. (D) After superficial parotidectomy, histological
examination revealed predominantly irregularly shaped microcysts of
varying sizes, lined by round to oval tumor cells and containing
light basophilic secretions within the lumina (hematoxylin and
eosin staining). (E) Immunohistochemical examination revealed that
S-100 protein was weakly and diffusely expressed in the nucleus and
cytoplasm of tumor cells. (F) Mammaglobin was strongly expressed in
the cytoplasm, whereas (G) cytokeratin 7 was expressed in both the
membrane and cytoplasm. (H) Sanger sequencing revealed an
ETV6::NTRK3 gene fusion point between exon 5 of the ETV6
gene (NM_001987.5) and exon 15 of the NTRK3 gene
(NM_002530.4). Based on the histological features,
immunohistochemical profile and molecular findings, the tumor was
diagnosed as secretory carcinoma and staged as pT1N1M0 (pStage
III). White scale bars, 1 cm; black scale bars, 50 µm.

Figure 2

Imaging and histological findings of
case 2. (A) Ultrasonography revealed an irregular, marginated,
heterogeneous, hypoechoic mass measuring 21x16x15 mm. MRI revealed
a solid tumor located in the anterior part of the right parotid
gland, showing (B) low signal intensity on T1-weighted imaging and
(C) a mixture of intermediate and high signal intensity with
extension to the masseter muscle on T2-weighted imaging. (D)
Fluorodeoxyglucose-positron emission tomography/computed tomography
revealed increased uptake by the tumor. (E) Fine-needle aspiration
cytology with Papanicolaou staining demonstrated an irregular
cluster of atypical cells with nuclear overlap, vesicular chromatin
and prominent nucleoli, which was interpreted as suspicious for
malignancy. (F) After total parotidectomy with selective neck
dissection, histologic examination demonstrated infiltrative,
irregular sheets of atypical epithelial cells with vesicular
chromatin. The tumor cells exhibited prominent nucleoli, admixed
with microcysts containing light basophilic secretions within the
lumina, set in a hyalinized stroma (hematoxylin and eosin
staining). (G) Immunohistochemical examination revealed that S-100
protein was diffusely expressed in the nucleus and cytoplasm of
tumor cells. (H) Mammaglobin was focally expressed in the
cytoplasm, whereas (I) cytokeratin 7 was strongly expressed in both
the membrane and cytoplasm. (J) Sanger sequencing analysis revealed
the ETV6::NTRK3 gene fusion point. Based on these findings, the
tumor was diagnosed as secretory carcinoma and staged as pT4aN0M0
(pStage IVA). White scale bars, 1 cm; black scale bars, 50 µm.
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Copy and paste a formatted citation
Spandidos Publications style
Hayashi M, Bandoh N, Goto T, Hayashi S, Arima R, Nakamuta K, Isochi‑Yamaguchi T, Baba S, Kato Y, Takahara M, Takahara M, et al: Secretory carcinoma in the parotid gland: A case report. Mol Clin Oncol 25: 47, 2026.
APA
Hayashi, M., Bandoh, N., Goto, T., Hayashi, S., Arima, R., Nakamuta, K. ... Takei, H. (2026). Secretory carcinoma in the parotid gland: A case report. Molecular and Clinical Oncology, 25, 47. https://doi.org/10.3892/mco.2026.2956
MLA
Hayashi, M., Bandoh, N., Goto, T., Hayashi, S., Arima, R., Nakamuta, K., Isochi‑Yamaguchi, T., Baba, S., Kato, Y., Takahara, M., Takei, H."Secretory carcinoma in the parotid gland: A case report". Molecular and Clinical Oncology 25.1 (2026): 47.
Chicago
Hayashi, M., Bandoh, N., Goto, T., Hayashi, S., Arima, R., Nakamuta, K., Isochi‑Yamaguchi, T., Baba, S., Kato, Y., Takahara, M., Takei, H."Secretory carcinoma in the parotid gland: A case report". Molecular and Clinical Oncology 25, no. 1 (2026): 47. https://doi.org/10.3892/mco.2026.2956
Copy and paste a formatted citation
x
Spandidos Publications style
Hayashi M, Bandoh N, Goto T, Hayashi S, Arima R, Nakamuta K, Isochi‑Yamaguchi T, Baba S, Kato Y, Takahara M, Takahara M, et al: Secretory carcinoma in the parotid gland: A case report. Mol Clin Oncol 25: 47, 2026.
APA
Hayashi, M., Bandoh, N., Goto, T., Hayashi, S., Arima, R., Nakamuta, K. ... Takei, H. (2026). Secretory carcinoma in the parotid gland: A case report. Molecular and Clinical Oncology, 25, 47. https://doi.org/10.3892/mco.2026.2956
MLA
Hayashi, M., Bandoh, N., Goto, T., Hayashi, S., Arima, R., Nakamuta, K., Isochi‑Yamaguchi, T., Baba, S., Kato, Y., Takahara, M., Takei, H."Secretory carcinoma in the parotid gland: A case report". Molecular and Clinical Oncology 25.1 (2026): 47.
Chicago
Hayashi, M., Bandoh, N., Goto, T., Hayashi, S., Arima, R., Nakamuta, K., Isochi‑Yamaguchi, T., Baba, S., Kato, Y., Takahara, M., Takei, H."Secretory carcinoma in the parotid gland: A case report". Molecular and Clinical Oncology 25, no. 1 (2026): 47. https://doi.org/10.3892/mco.2026.2956
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