Effects of infrasound at 8 Hz 90 dB/130 dB on NMDAR1 expression and changes in intracellular calcium ion concentration in the hippocampus of rats

  • Authors:
    • Zhao-Hui Liu
    • Jing-Zao Chen
    • Lin Ye
    • Jing Liu
    • Jian-Yong Qiu
    • Jian Xu
    • Rui Lu
    • Xiao-Chao Yuan
    • Wen-Dong Zhang
    • Xiao-Fang Li
    • Gong Li
  • View Affiliations

  • Published online on: September 22, 2010     https://doi.org/10.3892/mmr.2010.369
  • Pages:917-921
0

Abstract

In the present study, we investigated the effect of infrasound on the expression of N-methyl-D-aspartate (NMDAR)1 as well as changes in intracellular calcium ion concentration ([Ca2+]i) in the hippocampus of rats. Sprague-Dawley (SD) rats were exposed for 2 h daily to infrasound at 8 Hz 90 dB or 130 dB, and NMDAR1 expression was examined on days 1, 7, 14, 21 and 28. The expression of NMDAR1 in the rat hippocampus upon exposure to infrasound at 8 Hz 90 dB sound pressure level (SPL) showed an initial decrease on day 1, an increase on days 7 and 14, a further decrease on day 21, and a return to normal levels on day 28. The peak level was observed on day 14 in every examined subregion of the hippocampus. By contrast, exposure to infrasound at 8 Hz 130 dB SPL had opposite effects, showing an increase on day 1, a decrease on day 7, a decrease to the lowest point on days 14, another increase on day 21 and a return to normal levels on day 28. The lowest expression of NMDAR1 was found in the CA1 and CA3 regions on day 14 and in the DG region on day 7 with exposure at 130 dB. There were significant differences in [Ca2+]i concentration on days 14 and 21 with infrasonic exposure at both 8 Hz 90 dB and 130 dB, but no significant differences in [Ca2+]i concentration on days 1, 7 and 28 compared to the control group. The highest [Ca2+]i level was noted on day 14 with infrasound exposure at 8 Hz 130 dB. These changes suggest that 8 Hz 90 dB/130 dB infrasound exposure induced certain reversible changes in NMDAR1 expression and [Ca2+]i concentration in hippocampal cells, which may influence mnemonic functions related to the hippocampus.

Related Articles

Journal Cover

November 2010
Volume 3 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Liu, Z., Chen, J., Ye, L., Liu, J., Qiu, J., Xu, J. ... Li, G. (2010). Effects of infrasound at 8 Hz 90 dB/130 dB on NMDAR1 expression and changes in intracellular calcium ion concentration in the hippocampus of rats. Molecular Medicine Reports, 3, 917-921. https://doi.org/10.3892/mmr.2010.369
MLA
Liu, Z., Chen, J., Ye, L., Liu, J., Qiu, J., Xu, J., Lu, R., Yuan, X., Zhang, W., Li, X., Li, G."Effects of infrasound at 8 Hz 90 dB/130 dB on NMDAR1 expression and changes in intracellular calcium ion concentration in the hippocampus of rats". Molecular Medicine Reports 3.6 (2010): 917-921.
Chicago
Liu, Z., Chen, J., Ye, L., Liu, J., Qiu, J., Xu, J., Lu, R., Yuan, X., Zhang, W., Li, X., Li, G."Effects of infrasound at 8 Hz 90 dB/130 dB on NMDAR1 expression and changes in intracellular calcium ion concentration in the hippocampus of rats". Molecular Medicine Reports 3, no. 6 (2010): 917-921. https://doi.org/10.3892/mmr.2010.369