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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2011 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells

  • Authors:
    • Eun-Mi Noh
    • Young-Rae Lee
    • Kee-Oh Chay
    • Eun-Yong Chung
    • Sung Hoo Jung
    • Jong-Suk Kim
    • Hyun Jo Youn

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju 561-180, Korea, Department of Surgery, Chonbuk National University Medical School, Jeonju 560-180, Korea
  • Pages: 215-219
    |
    Published online on: January 3, 2011
       https://doi.org/10.3892/mmr.2011.412
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Abstract

Estrogen receptor α (ERα) mediates most of the biological effects of estrogen in mammary epithelial cells and stimulates growth signals involving phosphoinositide-3-OH kinase (PI3K)/Akt in breast cancer cells. Phosphatase and tensin homologue (PTEN) is a critical counter-regulator of PI3K signaling and is thus one of the major tumor suppressors in breast cancer. Inhibition of PI3K with an inhibitor, wortmannin, increased the level of PTEN protein in ERα-positive MCF-7 cells, while levels in ERα-negative MDA-MB 231 cells were not altered. In addition, the level of PTEN protein in MCF-7 cells was significantly lower than that in MDA-MB 231 cells, which correlated with high levels of phospho-Akt and phosphatidylinositol-3,4,5,-trisphosphate (PIP3). However, PTEN mRNA expression as measured by real-time PCR showed no differences in either cell line. Notably, the levels of casein kinase 2 (CK2) and phospho-PTEN (Ser380/Thr382/383) in MCF-7 cells were lower than those in MDA-MB 231 cells, indicating that the down-regulation of PTEN protein in MCF-7 cells is caused by low levels of CK2 expression, leading to accelerated PTEN degradation. Collectively, these results suggest that ERα induces the down-regulation of PTEN through PI3K activation in breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Noh E, Lee Y, Chay K, Chung E, Jung SH, Kim J and Youn HJ: Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. Mol Med Rep 4: 215-219, 2011.
APA
Noh, E., Lee, Y., Chay, K., Chung, E., Jung, S.H., Kim, J., & Youn, H.J. (2011). Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. Molecular Medicine Reports, 4, 215-219. https://doi.org/10.3892/mmr.2011.412
MLA
Noh, E., Lee, Y., Chay, K., Chung, E., Jung, S. H., Kim, J., Youn, H. J."Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells". Molecular Medicine Reports 4.2 (2011): 215-219.
Chicago
Noh, E., Lee, Y., Chay, K., Chung, E., Jung, S. H., Kim, J., Youn, H. J."Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells". Molecular Medicine Reports 4, no. 2 (2011): 215-219. https://doi.org/10.3892/mmr.2011.412
Copy and paste a formatted citation
x
Spandidos Publications style
Noh E, Lee Y, Chay K, Chung E, Jung SH, Kim J and Youn HJ: Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. Mol Med Rep 4: 215-219, 2011.
APA
Noh, E., Lee, Y., Chay, K., Chung, E., Jung, S.H., Kim, J., & Youn, H.J. (2011). Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. Molecular Medicine Reports, 4, 215-219. https://doi.org/10.3892/mmr.2011.412
MLA
Noh, E., Lee, Y., Chay, K., Chung, E., Jung, S. H., Kim, J., Youn, H. J."Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells". Molecular Medicine Reports 4.2 (2011): 215-219.
Chicago
Noh, E., Lee, Y., Chay, K., Chung, E., Jung, S. H., Kim, J., Youn, H. J."Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells". Molecular Medicine Reports 4, no. 2 (2011): 215-219. https://doi.org/10.3892/mmr.2011.412
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