The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus

  • Authors:
    • Jing Tian
    • Yan Ma
    • Jing Li
    • Han Cen
    • De-Guang Wang
    • Chen-Chen Feng
    • Ruo-Jie Li
    • Rui-Xue Leng
    • Hai-Feng Pan
    • Dong-Qing Ye
  • View Affiliations

  • Published online on: April 11, 2012     https://doi.org/10.3892/mmr.2012.865
  • Pages: 105-110
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder that predominantly affects women of childbearing age, with a female-to-male ratio of approximately 9:1. Previous findings indicated that male cases of SLE were associated with Klinefelter's syndrome (47, XXY), whereas females with Turner's syndrome (45, X0) did not contract SLE. Additionally, duplicated Toll-like receptor 7 (TLR7) was found to promote lupus-like disease. Consequently, the aim of this study was to evaluate whether the TLR7 gene served as a genetic marker for the development of SLE. A case-control study was performed on one tag single nucleotide polymorphism TLR7 rs1634323 in a population with 507 SLE patients and 513 healthy controls. Genotyping was determined by the TaqMan genotyping assay using the ABI 7300 real‑time reverse transcription polymerase chain reaction system. The results showed a significantly elevated risk of SLE with the rs1634323 AG genotype in females (P=0.040, OR=1.897, 95% CI 1.031-3.491), whereas a similar association was not replicated in males (P=0.303, OR=0.338, 95% CI 0.043-2.656). In a subgroup analysis by clinical manifestation of lupus nephritis, no significant differences were found. These findings indicate that the TLR7 gene rs1634323 polymorphism may contribute to SLE susceptibility in females.

Related Articles

Journal Cover

July 2012
Volume 6 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tian J, Ma Y, Li J, Cen H, Wang D, Feng C, Li R, Leng R, Pan H, Ye D, Ye D, et al: The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus. Mol Med Rep 6: 105-110, 2012.
APA
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C. ... Ye, D. (2012). The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus. Molecular Medicine Reports, 6, 105-110. https://doi.org/10.3892/mmr.2012.865
MLA
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C., Li, R., Leng, R., Pan, H., Ye, D."The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus". Molecular Medicine Reports 6.1 (2012): 105-110.
Chicago
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C., Li, R., Leng, R., Pan, H., Ye, D."The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus". Molecular Medicine Reports 6, no. 1 (2012): 105-110. https://doi.org/10.3892/mmr.2012.865