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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July 2012 Volume 6 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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Article

The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus

  • Authors:
    • Jing Tian
    • Yan Ma
    • Jing Li
    • Han Cen
    • De-Guang Wang
    • Chen-Chen Feng
    • Ruo-Jie Li
    • Rui-Xue Leng
    • Hai-Feng Pan
    • Dong-Qing Ye

  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 105-110
    |
    Published online on: April 11, 2012
       https://doi.org/10.3892/mmr.2012.865
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Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder that predominantly affects women of childbearing age, with a female-to-male ratio of approximately 9:1. Previous findings indicated that male cases of SLE were associated with Klinefelter's syndrome (47, XXY), whereas females with Turner's syndrome (45, X0) did not contract SLE. Additionally, duplicated Toll-like receptor 7 (TLR7) was found to promote lupus-like disease. Consequently, the aim of this study was to evaluate whether the TLR7 gene served as a genetic marker for the development of SLE. A case-control study was performed on one tag single nucleotide polymorphism TLR7 rs1634323 in a population with 507 SLE patients and 513 healthy controls. Genotyping was determined by the TaqMan genotyping assay using the ABI 7300 real‑time reverse transcription polymerase chain reaction system. The results showed a significantly elevated risk of SLE with the rs1634323 AG genotype in females (P=0.040, OR=1.897, 95% CI 1.031-3.491), whereas a similar association was not replicated in males (P=0.303, OR=0.338, 95% CI 0.043-2.656). In a subgroup analysis by clinical manifestation of lupus nephritis, no significant differences were found. These findings indicate that the TLR7 gene rs1634323 polymorphism may contribute to SLE susceptibility in females.

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Copy and paste a formatted citation
Spandidos Publications style
Tian J, Ma Y, Li J, Cen H, Wang D, Feng C, Li R, Leng R, Pan H, Ye D, Ye D, et al: The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus. Mol Med Rep 6: 105-110, 2012.
APA
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C. ... Ye, D. (2012). The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus. Molecular Medicine Reports, 6, 105-110. https://doi.org/10.3892/mmr.2012.865
MLA
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C., Li, R., Leng, R., Pan, H., Ye, D."The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus". Molecular Medicine Reports 6.1 (2012): 105-110.
Chicago
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C., Li, R., Leng, R., Pan, H., Ye, D."The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus". Molecular Medicine Reports 6, no. 1 (2012): 105-110. https://doi.org/10.3892/mmr.2012.865
Copy and paste a formatted citation
x
Spandidos Publications style
Tian J, Ma Y, Li J, Cen H, Wang D, Feng C, Li R, Leng R, Pan H, Ye D, Ye D, et al: The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus. Mol Med Rep 6: 105-110, 2012.
APA
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C. ... Ye, D. (2012). The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus. Molecular Medicine Reports, 6, 105-110. https://doi.org/10.3892/mmr.2012.865
MLA
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C., Li, R., Leng, R., Pan, H., Ye, D."The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus". Molecular Medicine Reports 6.1 (2012): 105-110.
Chicago
Tian, J., Ma, Y., Li, J., Cen, H., Wang, D., Feng, C., Li, R., Leng, R., Pan, H., Ye, D."The TLR7 7926A>G polymorphism is associated with susceptibility to systemic lupus erythematosus". Molecular Medicine Reports 6, no. 1 (2012): 105-110. https://doi.org/10.3892/mmr.2012.865
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