|
1
|
Iba T, Helms J and Levy JH: Sepsis-induced
coagulopathy (SIC) in the management of sepsis. Ann Intensive Care.
14:1482024. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Girardis M, David S, Ferrer R, Helms J,
Juffermans NP, Martin-Loeches I, Povoa P, Russell L, Shankar-Hari
M, Iba T, et al: Understanding, assessing and treating immune,
endothelial and haemostasis dysfunctions in bacterial sepsis.
Intensive Care Med. 50:1580–1592. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Xia T, Yu J, Du M, Chen X, Wang C and Li
R: Vascular endothelial cell injury: Causes, molecular mechanisms,
and treatments. MedComm (2020). 6:e700572025. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Schmoch T, Mohnle P, Weigand MA, Briegel
J, Bauer M, Bloos F, Briegel J, Radke DI, Bauer M, Bloos F, et al:
The prevalence of sepsis-induced coagulopathy in patients with
sepsis-a secondary analysis of two German multicenter randomized
controlled trials. Ann Intensive Care. 13:32023. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Matsuoka T, Yamakawa K, Umemura Y, Homma
K, Iba T and Sasaki J: The transition of the criteria for
disseminated intravascular coagulation and the targeted patients in
randomized controlled trials over the decades: A scoping review.
Thromb J. 22:1122024. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Middleton EA, He XY, Denorme F, Campbell
RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC,
Loda M, et al: Neutrophil extracellular traps contribute to
immunothrombosis in COVID-19 acute respiratory distress syndrome.
Blood. 136:1169–1179. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Zhu S, Yu Y, Qu M, Qiu Z, Zhang H, Miao C
and Guo K: Neutrophil extracellular traps contribute to
immunothrombosis formation via the STING pathway in
sepsis-associated lung injury. Cell Death Discov. 9:3152023.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhang H, Wang Y, Qu M, Li W, Wu D, Cata JP
and Miao C: Neutrophil, neutrophil extracellular traps and
endothelial cell dysfunction in sepsis. Clin Transl Med.
13:e11702023. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Iba T and Levy JH: Inflammation and
thrombosis: Roles of neutrophils, platelets and endothelial cells
and their interactions in thrombus formation during sepsis. J
Thromb Haemost. 16:231–241. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Dehghani T and Panitch A: Endothelial
cells, neutrophils and platelets: Getting to the bottom of an
inflammatory triangle. Open Biol. 10:2001612020. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang Y and Liu Y: Neutrophil-induced liver
injury and interactions between neutrophils and liver sinusoidal
endothelial cells. Inflammation. 44:1246–1262. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Castanheira FVS and Kubes P: Neutrophils
and NETs in modulating acute and chronic inflammation. Blood.
133:2178–2185. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Rudd KE, Johnson SC, Agesa KM, Shackelford
KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer
S, et al: Global, regional, and national sepsis incidence and
mortality, 1990–2017: Analysis for the global burden of disease
study. Lancet. 395:200–211. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Thompson KJ, Finfer SR, Woodward M, Leong
RNF and Liu B: Sex differences in sepsis hospitalisations and
outcomes in older women and men: A prospective cohort study. J
Infect. 84:770–776. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Angele MK, Pratschke S, Hubbard WJ and
Chaudry IH: Gender differences in sepsis: Cardiovascular and
immunological aspects. Virulence. 5:12–19. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Dockman RL, Carpenter JM, Diaz AN, Benbow
RA and Filipov NM: Sex differences in behavior, response to LPS,
and glucose homeostasis in middle-aged mice. Behav Brain Res.
418:1136282022. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Sarkar P, Mazgaeen L, Saini S, Gautam N,
Paden A, Paton H, Boevers P, Duvall J, Parlet C, Bermick J and
Gurung P: Neutrophils are key modulators of sex differences in
LPS-induced shock in mice. Blood Vessel Thromb Hemost.
2:1001042025. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Iba T, Helms J, Connors JM and Levy JH:
The pathophysiology, diagnosis, and management of sepsis-associated
disseminated intravascular coagulation. J Intensive Care.
11:242023. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Tan R, Ge C, Wang J, Yang Z, Guo H, Yan Y
and Du Q: Interpretable machine learning model for early morbidity
risk prediction in patients with sepsis-induced coagulopathy: A
multi-center study. Front Immunol. 16:15522652025. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Williams B, Zou L, Pittet JF and Chao W:
Sepsis-induced coagulopathy: A comprehensive narrative review of
pathophysiology, clinical presentation, diagnosis, and management
strategies. Anesth Analg. 138:696–711. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yajnik V and Maarouf R: Sepsis and the
microcirculation: The impact on outcomes. Curr Opin Anaesthesiol.
35:230–235. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Rovas A, Seidel LM, Vink H, Pohlkotter T,
Pavenstadt H, Ertmer C, Hessler M and Kümpers P: Association of
sublingual microcirculation parameters and endothelial glycocalyx
dimensions in resuscitated sepsis. Crit Care. 23:2602019.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Bateman RM, Sharpe MD, Jagger JE and Ellis
CG: Sepsis impairs microvascular autoregulation and delays
capillary response within hypoxic capillaries. Crit Care.
19:3892015. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
De Backer D, Ricottilli F and
Ospina-Tascon GA: Septic shock: A microcirculation disease. Curr
Opin Anaesthesiol. 34:85–91. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Colbert JF and Schmidt EP: Endothelial and
microcirculatory function and dysfunction in sepsis. Clin Chest
Med. 37:263–275. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Li X, Sim MMS and Wood JP: Recent insights
into the regulation of coagulation and thrombosis. Arterioscler
Thromb Vasc Biol. 40:e119–e125. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Yang X, Cheng X, Tang Y, Qiu X, Wang Y,
Kang H, Wu J, Wang Z, Liu Y, Chen F, et al: Bacterial endotoxin
activates the coagulation cascade through gasdermin D-dependent
phosphatidylserine exposure. Immunity. 51:983–996. e62019.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Deng M, Tang Y, Li W, Wang X, Zhang R,
Zhang X, Zhao X, Liu J, Tang C, Liu Z, et al: The endotoxin
delivery protein HMGB1 mediates caspase-11-dependent lethality in
sepsis. Immunity. 49:740–753. e72018. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Rodrigues M, Kosaric N, Bonham CA and
Gurtner GC: Wound healing: A cellular perspective. Physiol Rev.
99:665–706. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Bloom SI, Islam MT, Lesniewski LA and
Donato AJ: Mechanisms and consequences of endothelial cell
senescence. Nat Rev Cardiol. 20:38–51. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Schlommer C, Brandtner A and Bachler M:
Antithrombin and its role in host defense and inflammation. Int J
Mol Sci. 22:42832021. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Wilhelm AR, Parsons NA, Samelson-Jones BJ,
Davidson RJ, Esmon CT, Camire RM and George LA: Activated protein C
has a regulatory role in factor VIII function. Blood.
137:2532–2543. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Li X, Song X, Mahmood DFD, Sim MMS,
Bidarian SJ and Wood JP: Activated protein C, protein S, and tissue
factor pathway inhibitor cooperate to inhibit thrombin activation.
Thromb Res. 230:84–93. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Guo H, Liu D, Gelbard H, Cheng T, Insalaco
R, Fernandez JA, Griffin JH and Zlokovic BV: Activated protein C
prevents neuronal apoptosis via protease activated receptors 1 and
3. Neuron. 111:41162023. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
de Nooijer AH, Kotsaki A, Kranidioti E,
Kox M, Pickkers P, Toonen EJM, Giamarellos-Bourboulis EJ and Netea
MG: Complement activation in severely ill patients with sepsis: No
relationship with inflammation and disease severity. Crit Care.
27:632023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Noris M and Galbusera M: The complement
alternative pathway and hemostasis. Immunol Rev. 313:139–161. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Rawish E, Sauter M, Sauter R, Nording H
and Langer HF: Complement, inflammation and thrombosis. Br J
Pharmacol. 178:2892–2904. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Andrieux P, Chevillard C, Cunha-Neto E and
Nunes JPS: Mitochondria as a cellular hub in infection and
inflammation. Int J Mol Sci. 22:113382021. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Flora GD, Nayak MK, Ghatge M, Kumskova M,
Patel RB and Chauhan AK: Mitochondrial pyruvate dehydrogenase
kinases contribute to platelet function and thrombosis in mice by
regulating aerobic glycolysis. Blood Adv. 7:2347–2359. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Hidalgo A, Libby P, Soehnlein O, Aramburu
IV, Papayannopoulos V and Silvestre-Roig C: Neutrophil
extracellular traps: from physiology to pathology. Cardiovasc Res.
118:2737–2753. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Breda LCD, Breda CNS, de Almeida JRF,
Paulo LNM, Jannuzzi GP, Menezes IG, Albuquerque RC, Câmara NOS,
Ferreira KS and de Almeida SR: Fonsecaeapedrosoi conidia and hyphae
activate neutrophils distinctly: Requirement of TLR-2 and TLR-4 in
neutrophil effector functions. Front Immunol. 11:5400642020.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Shao Y, Guo Z, Yang Y, Liu L, Huang J,
Chen Y, Li L and Sun B: Neutrophil extracellular traps contribute
to myofibroblast differentiation and scar hyperplasia through the
Toll-like receptor 9/nuclear factor Kappa-B/interleukin-6 pathway.
Burns Trauma. 10:tkac0442022. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Wigerblad G and Kaplan MJ: Neutrophil
extracellular traps in systemic autoimmune and autoinflammatory
diseases. Nat Rev Immunol. 23:274–288. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Wang Y, Du C, Zhang Y and Zhu L:
Composition and function of neutrophil extracellular traps.
Biomolecules. 14:4162024. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Jiang X, Li Q, Huang R, Qian Y, Jiang Y,
Liu T, Wang Y, Hu K, Huang J, Huang W, et al: Giardia duodenalis
triggered neutrophil extracellular traps in goats. Immunobiology.
230:1528942025. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Huang J, Hong W, Wan M and Zheng L:
Molecular mechanisms and therapeutic target of NETosis in diseases.
MedComm (2020). 3:e1622022. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Mou Z, Chen Y, Hu J, Hu Y, Zou L, Chen X,
Liu S, Yin Q, Gong J, Li S, et al: Icaritin inhibits the
progression of urothelial cancer by suppressing PADI2-mediated
neutrophil infiltration and neutrophil extracellular trap
formation. Acta Pharm Sin B. 14:3916–3930. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Burgener SS and Schroder K: Neutrophil
extracellular traps in host defense. Cold Spring Harb Perspect
Biol. 12:a0370282020. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Zou S, Han X, Luo S, Tan Q, Huang H, Yao
Z, Hou W, Jie H and Wang J: Bay-117082 treats sepsis by inhibiting
neutrophil extracellular traps (NETs) formation through
down-regulating NLRP3/N-GSDMD. Int Immunopharmacol. 141:1128052024.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Gosswein S, Lindemann A, Mahajan A,
Maueroder C, Martini E, Patankar J, Schett G, Becker C, Wirtz S,
Naumann-Bartsch N, et al: Citrullination licenses calpain to
decondense nuclei in neutrophil extracellular trap formation. Front
Immunol. 10:24812019. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Thirugnanasambandham I, Radhakrishnan A,
Kuppusamy G, Singh SK and Dua K: Peptidylarginine deiminase-4:
Medico-formulative strategy towards management of rheumatoid
arthritis. Biochem Pharmacol. 200:1150402022. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Singhal A and Kumar S: Neutrophil and
remnant clearance in immunity and inflammation. Immunology.
165:22–43. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Akk A, Springer LE and Pham CT: Neutrophil
extracellular traps enhance early inflammatory response in sendai
virus-induced asthma phenotype. Front Immunol. 7:3252016.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Liu X, Arfman T, Wichapong K,
Reutelingsperger CPM, Voorberg J and Nicolaes GAF: PAD4 takes
charge during neutrophil activation: Impact of PAD4 mediated NET
formation on immune-mediated disease. J Thromb Haemost.
19:1607–1617. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Lv G, Wang H, Wang J, Lian S and Wu R:
Effect of BLV infection on the immune function of polymorphonuclear
neutrophil in dairy cows. Front Vet Sci. 8:7376082021. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Yousefi S, Mihalache C, Kozlowski E,
Schmid I and Simon HU: Viable neutrophils release mitochondrial DNA
to form neutrophil extracellular traps. Cell Death Differ.
16:1438–1444. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Denning NL, Aziz M, Gurien SD and Wang P:
DAMPs and NETs in sepsis. Front Immunol. 10:25362019. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Xia L, Yan X and Zhang H: Mitochondrial
DNA-activated cGAS-STING pathway in cancer: Mechanisms and
therapeutic implications. Biochim Biophys Acta Rev Cancer.
1880:1892492025. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Liu L, Mao Y, Xu B, Zhang X, Fang C, Ma Y,
Men K, Qi X, Yi T, Wei Y and Wei X: Induction of neutrophil
extracellular traps during tissue injury: Involvement of STING and
toll-like receptor 9 pathways. Cell Prolif. 53:e127752020.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Zheng Y, Zhu Y, Liu X, Zheng H, Yang Y, Lu
Y, Zhou H, Zheng J and Dong Z: The screening of albumin as a key
serum component in preventing release of neutrophil extracellular
traps by selectively inhibiting mitochondrial ROS generation. Can J
Physiol Pharmacol. 99:427–438. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Zeng FL, Zhang Y, Wang ZH, Zhang H, Meng
XT, Wu YQ, Qian ZZ, Ding YH, Li J, Ma TT and Huang C: Neutrophil
extracellular traps promote acetaminophen-induced acute liver
injury in mice via AIM2. Acta Pharmacol Sin. 45:1660–1672. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Chen KW, Monteleone M, Boucher D,
Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ
and Schroder K: Noncanonical inflammasome signaling elicits
gasdermin D-dependent neutrophil extracellular traps. Sci Immunol.
3:eaar66762018. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Zhou L, Li Y, You J, Wu C, Zuo L, Chen Y,
Kang L, Zhou Z, Huang R and Wu S: Salmonella spvC gene suppresses
macrophage/neutrophil antibacterial defense mediated by gasdermin
D. Inflamm Res. 73:19–33. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Iba T, Levy JH, Raj A and Warkentin TE:
Advance in the management of sepsis-induced coagulopathy and
disseminated intravascular coagulation. J Clin Med. 8:7282019.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Fei Y and Huang X, Ning F, Qian T, Cui J,
Wang X and Huang X: NETs induce ferroptosis of endothelial cells in
LPS-ALI through SDC-1/HS and downstream pathways. Biomed
Pharmacother. 175:1166212024. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Folco EJ, Mawson TL, Vromman A,
Bernardes-Souza B, Franck G, Persson O, Nakamura M, Newton G,
Luscinskas FW and Libby P: Neutrophil extracellular traps induce
endothelial cell activation and tissue factor production through
interleukin-1alpha and cathepsin G. Arterioscler Thromb Vasc Biol.
38:1901–1912. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Shan X, Yu S, Tang Z, Yang P and Dong L:
GSDMD-NETs in patients with sepsis-induced coagulopathy and their
interaction with glycocalyx damage. Front Immunol. 16:16241282025.
View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Fang J, Ding H, Huang J, Liu W, Hong T,
Yang J, Wu Z, Li Z, Zhang S, Liu P, et al: Mac-1 blockade impedes
adhesion-dependent neutrophil extracellular trap formation and
ameliorates lung injury in LPS-induced sepsis. Front Immunol.
16:15489132025. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Li Y, Zhu H, Liu Y, Li X, Zu X, Wang C, Xu
X, Sun Y, Dai Y, Zhang J, et al: STK10 regulates platelet function
in arterial thrombosis and thromboinflammation. Blood. 147:73–86.
2026. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Jiang H, Chen S, Gui X, Li Y, Sun Y, Zhu
H, Dai Y, Zhang J, Li X, Ju W, et al: Platelet NLRP6 protects
against microvascular thrombosis in sepsis. Blood. 146:382–395.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Hvas AM, Favaloro EJ and Hellfritzsch M:
Heparin-induced thrombocytopenia: Pathophysiology, diagnosis and
treatment. Expert Rev Hematol. 14:335–346. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Perdomo J, Leung HHL, Ahmadi Z, Yan F,
Chong JJH, Passam FH and Chong BH: Neutrophil activation and
NETosis are the major drivers of thrombosis in heparin-induced
thrombocytopenia. Nat Commun. 10:13222019. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Leung HHL, Perdomo J, Ahmadi Z, Yan F,
McKenzie SE and Chong BH: Inhibition of NADPH oxidase blocks
NETosis and reduces thrombosis in heparin-induced thrombocytopenia.
Blood Adv. 5:5439–5451. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Li J, Geng Y, Luo Y, Sun X, Guo Y and Dong
Z: Pathological roles of NETs-platelet synergy in thrombotic
diseases: From molecular mechanisms to therapeutic targeting. Int
Immunopharmacol. 159:1149342025. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Thalin C, Hisada Y, Lundstrom S, Mackman N
and Wallen H: Neutrophil extracellular traps: villains and targets
in arterial, venous, and cancer-associated thrombosis. Arterioscler
Thromb Vasc Biol. 39:1724–1738. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Zhou P, Li T, Jin J, Liu Y, Li B, Sun Q,
Tian J, Zhao H, Liu Z, Ma S, et al: Interactions between neutrophil
extracellular traps and activated platelets enhance procoagulant
activity in acute stroke patients with ICA occlusion. EBioMedicine.
53:1026712020. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Pignataro G, Gemma S, Petrucci M, Barone
F, Piccioni A, Franceschi F and Candelli M: Unraveling NETs in
sepsis: From cellular mechanisms to clinical relevance. Int J Mol
Sci. 26:74642025. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Zhao Z, Pan Z, Zhang S, Ma G, Zhang W,
Song J, Wang Y, Kong L and Du G: Neutrophil extracellular traps: A
novel target for the treatment of stroke. Pharmacol Ther.
241:1083282023. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Reyes-Garcia AML, Aroca A, Arroyo AB,
Garcia-Barbera N, Vicente V, Gonzalez-Conejero R and Martínez C:
Neutrophil extracellular trap components increase the expression of
coagulation factors. Biomed Rep. 10:195–201. 2019.PubMed/NCBI
|
|
80
|
Rao AN, Kazzaz NM and Knight JS: Do
neutrophil extracellular traps contribute to the heightened risk of
thrombosis in inflammatory diseases? World J Cardiol. 7:829–842.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Demyanets S, Stojkovic S, Mauracher LM,
Kopp CW, Wojta J, Thaler J, Panzer S and Gremmel T: Surrogate
markers of neutrophil extracellular trap formation are associated
with ischemic outcomes and platelet activation after peripheral
angioplasty and stenting. J Clin Med. 9:3042020. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Li RHL and Tablin F: A comparative review
of neutrophil extracellular traps in sepsis. Front Vet Sci.
5:2912018. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Thomassen M, Bouwens BRC, Wichapong K,
Suylen DP, Bouwman FG, Hackeng TM and Koenen RR: Protein arginine
deiminase 4 inactivates tissue factor pathway inhibitor-alpha by
enzymatic modification of functional arginine residues. J Thromb
Haemost. 21:1214–1226. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Asakura H: Classifying types of
disseminated intravascular coagulation: Clinical and animal models.
J Intensive Care. 2:202014. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Varju I, Longstaff C, Szabo L, Farkas AZ,
Varga-Szabo VJ, Tanka-Salamon A, Machovich R and Kolev K: DNA,
histones and neutrophil extracellular traps exert anti-fibrinolytic
effects in a plasma environment. Thromb Haemost. 113:1289–1298.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Mangold A, Alias S, Scherz T, Hofbauer M,
Jakowitsch J, Panzenbock A, Simon D, Laimer D, Bangert C,
Kammerlander A, et al: Coronary neutrophil extracellular trap
burden and deoxyribonuclease activity in ST-elevation acute
coronary syndrome are predictors of ST-segment resolution and
infarct size. Circ Res. 116:1182–1192. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Yang LY, Luo Q, Lu L, Zhu WW, Sun HT, Wei
R, Lin ZF, Wang XY, Wang CQ, Lu M, et al: Increased neutrophil
extracellular traps promote metastasis potential of hepatocellular
carcinoma via provoking tumorous inflammatory response. J Hematol
Oncol. 13:32020. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Xu C, Ye Z, Jiang W, Wang S and Zhang H:
Cyclosporine A alleviates colitis by inhibiting the formation of
neutrophil extracellular traps via the regulating pentose phosphate
pathway. Mol Med. 29:1692023. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Li Y, Li H, Wang Y, Guo J and Zhang D:
Potential biomarkers for early diagnosis, evaluation, and prognosis
of sepsis-induced coagulopathy. Clin Appl Thromb Hemost.
29:107602962311950892023. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Zhao J, Zhen N, Zhou Q, Lou J, Cui W,
Zhang G and Tian B: NETs promote inflammatory injury by activating
cGAS-STING pathway in acute lung injury. Int J Mol Sci.
24:51252023. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Mai SH, Khan M, Dwivedi DJ, Ross CA, Zhou
J, Gould TJ, Gross PL, Weitz JI, Fox-Robichaud AE and Liaw PC;
Canadian Critical Care Translational Biology Group, : Delayed but
not early treatment with dnase reduces organ damage and improves
outcome in a murine model of sepsis. Shock. 44:166–172. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Zalghout S and Martinod K: Therapeutic
potential of DNases in immunothrombosis: Promising succor or
uncertain future? J Thromb Haemost. 23:760–778. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Cai M, Deng J, Wu S, Cao Y, Chen H, Tang
H, Zou C, Zhu H and Qi L: Alpha-1 antitrypsin targeted neutrophil
elastase protects against sepsis-induced inflammation and
coagulation in mice via inhibiting neutrophil extracellular trap
formation. Life Sci. 353:1229232024. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Liu X, Li T, Chen H, Yuan L and Ao H: Role
and intervention of PAD4 in NETs in acute respiratory distress
syndrome. Respir Res. 25:632024. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
He W, Xi Q, Cui H, Zhang P, Huang R, Wang
T and Wang D: Liang-ge decoction ameliorates coagulation
dysfunction in cecal ligation and puncture-induced sepsis model
rats through inhibiting PAD4-dependent neutrophil extracellular
trap formation. Evid Based Complement Alternat Med.
2023:50429532023. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Kato Y, Nishida O, Kuriyama N, Nakamura T,
Kawaji T, Onouchi T, Hasegawa D and Shimomura Y: Effects of
thrombomodulin in reducing lethality and suppressing neutrophil
extracellular trap formation in the lungs and liver in a
lipopolysaccharide-induced murine septic shock model. Int J Mol
Sci. 22:49332021. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Silva CMS, Wanderley CWS, Veras FP, Sonego
F, Nascimento DC, Goncalves AV, Martins TV, Cólon DF, Borges VF,
Brauer VS, et al: Gasdermin D inhibition prevents multiple organ
dysfunction during sepsis by blocking NET formation. Blood.
138:2702–2713. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Mansour A, Bachelot-Loza C, Nesseler N,
Gaussem P and Gouin-Thibault I: P2Y(12) inhibition beyond
thrombosis: effects on inflammation. Int J Mol Sci. 21:13912020.
View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Vardon-Bounes F, Ruiz S, Gratacap MP,
Garcia C, Payrastre B and Minville V: Platelets are critical key
players in sepsis. Int J Mol Sci. 20:34942019. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
A feedback loop between platelets and NETs
amplifies inflammation in severe sepsis. Nat Cardiovasc Res.
1:698–699. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Chen S, Wu A, Shen X, Kong J and Huang Y:
Disrupting the dangerous alliance: Dual anti-inflammatory and
anticoagulant strategy targets platelet-neutrophil crosstalk in
sepsis. J Control Release. 379:814–831. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Su F, Moreau A, Savi M, Salvagno M, Annoni
F, Zhao L, Xie K, Vincent JL and Taccone FS: Circulating
nucleosomes as a novel biomarker for sepsis: A scoping review.
Biomedicines. 12:13852024. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Cutter AR and Hayes JJ: A brief review of
nucleosome structure. FEBS Lett. 589((20 Pt A)): 2914–2922. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Chen L, Zhao Y, Lai D, Zhang P, Yang Y, Li
Y, Fei K, Jiang G and Fan J: Neutrophil extracellular traps promote
macrophage pyroptosis in sepsis. Cell Death Dis. 9:5972018.
View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Magna M and Pisetsky DS: The role of HMGB1
in the pathogenesis of inflammatory and autoimmune diseases. Mol
Med. 20:138–146. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Nija RJ, Sanju S, Sidharthan N and Mony U:
Extracellular trap by blood cells: Clinical implications. Tissue
Eng Regen Med. 17:141–153. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Loureiro A, Pais C and Sampaio P:
Relevance of macrophage extracellular traps in C. albicans killing.
Front Immunol. 10:27672019. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Koyama R, Arai T, Kijima M, Sato S, Miura
S, Yuasa M, Kitamura D and Mizuta R: DNase gamma, DNase I and
caspase-activated DNase cooperate to degrade dead cells. Genes
Cells. 21:1150–1163. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Janovicova L, Conka J, Laukova L and Celec
P: Variability of endogenous deoxyribonuclease activity and its
pathophysiological consequences. Mol Cell Probes. 65:1018442022.
View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Li Y, Wan D, Luo X, Song T, Wang Y, Yu Q,
Jiang L, Liao R, Zhao W and Su B: Circulating histones in sepsis:
Potential outcome predictors and therapeutic targets. Front
Immunol. 12:6501842021. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Garcia B, Su F, Dewachter L, Wang Y, Li N,
Remmelink M, Eycken MV, Khaldi A, Favory R, Herpain A, et al:
Neutralization of extracellular histones by sodium-Beta-O-methyl
cellobioside sulfate in septic shock. Crit Care. 27:4582023.
View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Ngo AT, Skidmore A, Oberg J, Yarovoi I,
Sarkar A, Levine N, Bochenek V, Zhao G, Rauova L, Kowalska MA, et
al: Platelet factor 4 limits neutrophil extracellular trap- and
cell-free DNA-induced thrombogenicity and endothelial injury. JCI
Insight. 8:e1710542023. View Article : Google Scholar : PubMed/NCBI
|
