Oncol Lett 21: [Related article:] 208, 2021; DOI:
10.3892/ol.2021.12469
Following the publication of the above paper, an
interested reader drew to the authors’ attention that, regarding
the cell migration and invasion assay data shown in Fig. 3A on p. 6, the 1 μM, 5 μM and 10 μM
(β-carotene) data panels, and the 1 μM (β-carotene)+PLX, 5 μM+PTX
and 10 μM+PTX data panels, contained a number of overlapping
sections, such that data which were intended to show the results of
six different experiments had apparently been derived from two
original sources.
After consulting their original data, the authors
have realized that the data in this figure were inadvertently
assembled incorrectly. To rectify this issue, the authors have
submitted a revised version of Fig.
3 featuring replacement data for Fig. 3A [which also entailed an updated
analytical approach that transitioned from cell counting to the
quantification of the migration cell area (%), thereby providing a
more precise and objective representation of the results], and this
is shown on the next page. The authors wish to highlight that the
results obtained were broadly similar to those included in the
published paper; however, some changes are necessary concerning the
description of these results in the article. Based on their refined
analysis, the relevant data have been updated: The migration cell
areas are now shown as 15.5% and 11.5% for 5 and 10 µM β-carotene
alone, respectively, compared with 34.3% in the control group.
Therefore, the text featured in the “β-carotene inhibits cell
invasion, but alleviates the inhibitory effect of PLX on cell
invasion” subsection of the Results (on p. 6–7) should now read
as follows (changes are highlighted in bold): “Since it was
reported that β-carotene inhibited lung metastasis of murine
melanoma in vivo (53) and inhibited migration and invasion
of human hepatocarcinoma cells in vitro (65), based on these
findings the present study examined the effects of β-carotene on
the invasive ability of A2058 human melanoma cells and on the
inhibitory effect of PLX4032 on cell invasion using a
Matrigel-coated Transwell cell invasion assay. β-carotene alone at
5 and 10 µM significantly decreased A2058 cell invasion across the
cell-permeable microporous membrane to 15.5% and 11.5% (migration
cell area), respectively, compared with 34.3% in the control group
(Fig. 3A and B). Notably,
β-carotene alleviated the inhibitory effect of PLX4032 on A2058
melanoma cell invasion (Fig. 3A and
B).”
The authors are grateful to the Editor of
Oncology Letters for allowing them this opportunity to
publish a Corrigendum, and all the authors agree with its
publication; moreover, they apologize for any inconvenience caused
to the readership.
