Single nucleotide polymorphisms in breast cancer

  • Authors:
    • Asta Försti
    • Sabrina Angelini
    • Fabiola Festa
    • Somali Sanyal
    • Zhenzhong Zhang
    • Ewa Grzybowska
    • Jolanta Pamula
    • Wioletta Pekala
    • Helena Zientek
    • Kari Hemminki
    • Rajiv Kumar
  • View Affiliations

  • Published online on: April 1, 2004     https://doi.org/10.3892/or.11.4.917
  • Pages: 917-922
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Abstract

A limited number of genes have been identified that explain heritable risks of breast cancer (BC). We searched for low-penetrant genes in an association study using two populations: 223 Finnish unselected patients and 172 Polish familial cases, both with locally collected healthy controls. Candidate genes included DNA repair genes, methylenetetrahydrofolate reductase (MTHFR) and cyclin D1 genes. The frequencies for single nucleotide polymorphisms (SNPs) were measured in the following genes: NBS1, XPC, XPD, XRCC1, XRCC3, MTHFR, and cyclin D1. Odds ratios (ORs) were calculated to the wild-type genotype. The positive findings in the Finnish series were repeated in the Polish series. Significant findings among Finns were associations to XPC exon 15, XPD exon 10 and XRCC3 exon 7, the latter of borderline significance. None of these results could be repeated in the Polish series. The XPC result among Finns was probably an artifact of the control group deviating from the Hardy-Weinberg Equilibrium (HWE). The attempt to repeat the result for the XPD polymorphism among Poles was probably not valid because the control group deviated from the HWE. We conclude that within statistical power of the present study, none of the tested polymorphisms associated with BC, with the probable exception of XPD.

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April 2004
Volume 11 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Försti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska E, Pamula J, Pekala W, Zientek H, Hemminki K, Hemminki K, et al: Single nucleotide polymorphisms in breast cancer. Oncol Rep 11: 917-922, 2004
APA
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E. ... Kumar, R. (2004). Single nucleotide polymorphisms in breast cancer. Oncology Reports, 11, 917-922. https://doi.org/10.3892/or.11.4.917
MLA
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R."Single nucleotide polymorphisms in breast cancer". Oncology Reports 11.4 (2004): 917-922.
Chicago
Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R."Single nucleotide polymorphisms in breast cancer". Oncology Reports 11, no. 4 (2004): 917-922. https://doi.org/10.3892/or.11.4.917