Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis

  • Authors:
    • Masaya Mukai
    • Shinkichi Sato
    • Takayuki Tajima
    • Hiromi Ninomiya
    • Tomomi Kimura
    • Nobukazu Komatsu
    • Hisao Nakasaki
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: November 1, 2004     https://doi.org/10.3892/or.12.5.1127
  • Pages: 1127-1130
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Abstract

This study was designed to compare the prediction of recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes or by using high-risk criteria for recurrence/metastasis in patients with Dukes' B colorectal cancer. Prediction of recurrence based on the detection of ONCs had a sensitivity of 59.1% (13/22), a false-positive rate of 7.8% (8/102), a specificity of 92.2% (94/102), and a negative predictive value (NPV) of 91.3% (94/103). Prediction of recurrence based on positivity for at least 2 of the 3 high-risk criteria had a sensitivity of 90.9% (20/22), a false-positive rate of 49.0% (50/102), a specificity of 51.0% (52/102), and an NPV of 96.3% (52/54). Among the 21 patients in whom ONCs were detected, prediction of recurrence based on the presence of all 3 high-risk criteria including ONCs had a sensitivity of 84.6% (11/13) and a positive predictive value (PPV) of 78.6% (11/14). These results suggest that colorectal cancer is unlikely to recur in patients without ONCs, while recurrence is likely in patients who fulfill 2 or more of the high-risk criteria. Accordingly, a combination of these parameters may be useful for the early prediction of recurrence/metastasis to assist in the choice of postoperative systemic chemotherapy.

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November 2004
Volume 12 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mukai M, Sato S, Tajima T, Ninomiya H, Kimura T, Komatsu N, Nakasaki H and Makuuchi H: Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis. Oncol Rep 12: 1127-1130, 2004
APA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Kimura, T., Komatsu, N. ... Makuuchi, H. (2004). Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis. Oncology Reports, 12, 1127-1130. https://doi.org/10.3892/or.12.5.1127
MLA
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Kimura, T., Komatsu, N., Nakasaki, H., Makuuchi, H."Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis". Oncology Reports 12.5 (2004): 1127-1130.
Chicago
Mukai, M., Sato, S., Tajima, T., Ninomiya, H., Kimura, T., Komatsu, N., Nakasaki, H., Makuuchi, H."Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis". Oncology Reports 12, no. 5 (2004): 1127-1130. https://doi.org/10.3892/or.12.5.1127