Prognostic role of cell apoptotic rate in prostate cancer: Outcome of a long-time follow-up study

  • Authors:
    • Giuseppe Dachille
    • Tommaso Cai
    • Giuseppe Mario Ludovico
    • Giovanni Vestita
    • Giovanni Pagliarulo
    • Gabriella Nesi
    • Sandra Mazzoli
    • Francesca Meacci
    • Nicola Mondaini
    • Beatrice Detti
    • Riccardo Bartoletti
  • View Affiliations

  • Published online on: February 1, 2008     https://doi.org/10.3892/or.19.2.541
  • Pages: 541-545
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Abstract

The tumour apoptotic pattern is described as a good predictor of outcome in patients with prostate cancer (PCa). So far no authors have evaluated the role of apoptotic characteristics in patients who have undergone radical prostatectomy (RRP) alone. The aim of the present study is to estimate the prognostic role of the apoptotic index (AI) in a group of patients with prostatic adenocarcinoma subjected to RRP with no adjuvant therapy. Fifty patients underwent RRP according to standardised techniques and the surgical specimens were analysed histologically. In order to evaluate the AI and correlate these results with the follow-up data, we used a standardised apoptotic regulatory terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine-triphosphate-biotin nick end-labelling technique (Becton Dickinson Immunocytometry Systems, San Jose, CA, USA). The mean follow-up period was 66 months. Significant correlations were found between the AI and pathological features, such as stage (p<0.001) and grade (p<0.001). Out of 50 patients, 13 (26%) had biochemical recurrence and clinical disease progression, with an AI of 1.93 (range, 0.76-5.22), while 37 patients (74%) who did not report any disease progression, had an AI of 0.58 (range, 0.1-3.12). Furthermore, the AI significantly correlated with status at the end of follow-up (r=0.75, p=0.002), these data being confirmed by Kaplan-Meier curve analysis (p<0.001). On multivariate analysis, the AI proved to be an independent prognostic factor of progression-free probability (p<0.001). Our results highlight the utility of AI analysis in assessing the probability risk of clinical progression in PCa patients who are treated with RRP.

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February 2008
Volume 19 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Dachille G, Cai T, Ludovico GM, Vestita G, Pagliarulo G, Nesi G, Mazzoli S, Meacci F, Mondaini N, Detti B, Detti B, et al: Prognostic role of cell apoptotic rate in prostate cancer: Outcome of a long-time follow-up study. Oncol Rep 19: 541-545, 2008
APA
Dachille, G., Cai, T., Ludovico, G.M., Vestita, G., Pagliarulo, G., Nesi, G. ... Bartoletti, R. (2008). Prognostic role of cell apoptotic rate in prostate cancer: Outcome of a long-time follow-up study. Oncology Reports, 19, 541-545. https://doi.org/10.3892/or.19.2.541
MLA
Dachille, G., Cai, T., Ludovico, G. M., Vestita, G., Pagliarulo, G., Nesi, G., Mazzoli, S., Meacci, F., Mondaini, N., Detti, B., Bartoletti, R."Prognostic role of cell apoptotic rate in prostate cancer: Outcome of a long-time follow-up study". Oncology Reports 19.2 (2008): 541-545.
Chicago
Dachille, G., Cai, T., Ludovico, G. M., Vestita, G., Pagliarulo, G., Nesi, G., Mazzoli, S., Meacci, F., Mondaini, N., Detti, B., Bartoletti, R."Prognostic role of cell apoptotic rate in prostate cancer: Outcome of a long-time follow-up study". Oncology Reports 19, no. 2 (2008): 541-545. https://doi.org/10.3892/or.19.2.541