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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2011 Volume 26 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma

  • Authors:
    • Abdel-Rahman N. Zekri
    • Abeer A. Bahnassy
    • Hanaa M. Alam El-Din
    • Heba M. Morsy
    • Sabry Shaarawy
    • Nagia Z. Moharram
    • Sayed S. Daoud

  • View Affiliations / Copyright

    Affiliations: Virology and Immunology Unit, Cancer Biology Department, Cairo University, Cairo, Egypt, Department of Pharmaceutical Sciences, Center for Integrated Biotechnology, 340D Wegner Hall, Pullman, WA 99164-6534, USA
  • Pages: 825-831
    |
    Published online on: June 21, 2011
       https://doi.org/10.3892/or.2011.1355
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Abstract

The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as potential diagnostic makers for HCV/genotype 4-associated HCC. Twenty cases of healthy subjects, 11 cases with asymptomatic HCV/genotype 4 carriers (ASC), 28 chronic hepatitis (CH) cases and 32 patients with HCC were enrolled in this study. Serum levels of proteins were measured by a sandwich-enzyme-linked (ELISA) assay. The diagnostic accuracy of each candidate marker was evaluated using receiver-operating characteristic (ROC) curve analysis, reporting the area under the curve (AUC) and its 95% confidence interval (CI). We demonstrated that serum β-catenin levels were significantly elevated in patients with HCC compared to those with CH, ASC and healthy controls. Among the six studied markers, β-catenin was also found to be the only marker that can significantly discriminate between patients with HCC and those with CH; therefore, β-catenin could be considered as a potential marker for early diagnosis of HCV-associated HCC in patients infected with HCV genotype 4.

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Copy and paste a formatted citation
Spandidos Publications style
Zekri AN, Bahnassy AA, Alam El-Din HM, Morsy HM, Shaarawy S, Moharram NZ and Daoud SS: Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. Oncol Rep 26: 825-831, 2011.
APA
Zekri, A.N., Bahnassy, A.A., Alam El-Din, H.M., Morsy, H.M., Shaarawy, S., Moharram, N.Z., & Daoud, S.S. (2011). Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. Oncology Reports, 26, 825-831. https://doi.org/10.3892/or.2011.1355
MLA
Zekri, A. N., Bahnassy, A. A., Alam El-Din, H. M., Morsy, H. M., Shaarawy, S., Moharram, N. Z., Daoud, S. S."Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma". Oncology Reports 26.4 (2011): 825-831.
Chicago
Zekri, A. N., Bahnassy, A. A., Alam El-Din, H. M., Morsy, H. M., Shaarawy, S., Moharram, N. Z., Daoud, S. S."Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma". Oncology Reports 26, no. 4 (2011): 825-831. https://doi.org/10.3892/or.2011.1355
Copy and paste a formatted citation
x
Spandidos Publications style
Zekri AN, Bahnassy AA, Alam El-Din HM, Morsy HM, Shaarawy S, Moharram NZ and Daoud SS: Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. Oncol Rep 26: 825-831, 2011.
APA
Zekri, A.N., Bahnassy, A.A., Alam El-Din, H.M., Morsy, H.M., Shaarawy, S., Moharram, N.Z., & Daoud, S.S. (2011). Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. Oncology Reports, 26, 825-831. https://doi.org/10.3892/or.2011.1355
MLA
Zekri, A. N., Bahnassy, A. A., Alam El-Din, H. M., Morsy, H. M., Shaarawy, S., Moharram, N. Z., Daoud, S. S."Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma". Oncology Reports 26.4 (2011): 825-831.
Chicago
Zekri, A. N., Bahnassy, A. A., Alam El-Din, H. M., Morsy, H. M., Shaarawy, S., Moharram, N. Z., Daoud, S. S."Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma". Oncology Reports 26, no. 4 (2011): 825-831. https://doi.org/10.3892/or.2011.1355
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