Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma

  • Authors:
    • Atsunori Oga
    • Kenichiro Uchida
    • Motonao Nakao
    • Shigeto Kawauchi
    • Tomoko Furuya
    • Yasuyo Chochi
    • Kenzo Ikemoto
    • Takae Okada
    • Yoshiya Ueyama
    • Kohsuke Sasaki
    • Fatemeh Yousefpour
  • View Affiliations

  • Published online on: September 5, 2011     https://doi.org/10.3892/or.2011.1446
  • Pages: 1393-1398
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We analyzed 10 adenoid cystic carcinomas (ACCs) of the salivary glands by array-based comparative genomic hybridization (a-CGH) using DNA chips spotted with 4,030 bacterial artificial chromosome clones. After the data smoothing procedure was applied, a total of 88 DNA copy number aberrations (DCNAs) were detected. The frequent (≥30%) DCNAs were loss of 6q23-27 and 8p23, and gains of 6p, 6q23, 8p23 and 22q13. High-level gains were detected on 12q15, including MDM2 in two cases. These two cases showed an immunohistochemically high-level (>50%) expression of MDM2 and a low-level expression of p53 (<20%). Furthermore, the total number of DCNAs was significantly greater in ACCs with loss of 6q compared to other ACCs, and in ACCs without the loss of 8p23 compared to other ACCs, respectively. Although limitations exist, a-CGH detected several candidate chromosomal imbalances associated with accumulation of DCNAs in ACCs.

Related Articles

Journal Cover

December 2011
Volume 26 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Oga A, Uchida K, Nakao M, Kawauchi S, Furuya T, Chochi Y, Ikemoto K, Okada T, Ueyama Y, Sasaki K, Sasaki K, et al: Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma. Oncol Rep 26: 1393-1398, 2011
APA
Oga, A., Uchida, K., Nakao, M., Kawauchi, S., Furuya, T., Chochi, Y. ... Yousefpour, F. (2011). Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma. Oncology Reports, 26, 1393-1398. https://doi.org/10.3892/or.2011.1446
MLA
Oga, A., Uchida, K., Nakao, M., Kawauchi, S., Furuya, T., Chochi, Y., Ikemoto, K., Okada, T., Ueyama, Y., Sasaki, K., Yousefpour, F."Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma". Oncology Reports 26.6 (2011): 1393-1398.
Chicago
Oga, A., Uchida, K., Nakao, M., Kawauchi, S., Furuya, T., Chochi, Y., Ikemoto, K., Okada, T., Ueyama, Y., Sasaki, K., Yousefpour, F."Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma". Oncology Reports 26, no. 6 (2011): 1393-1398. https://doi.org/10.3892/or.2011.1446