The molecular mechanisms of chemotherapeutic resistance in tumors (Review)

Weng,Xin; Zeng,Wei-Hong; Zhong,Li-Yuan; Xie,Li-Hua; Ge,Wen-Jun; Lai,Zhen; Qin,Qin; Liu,Peng; Cao,De-Liang; Zeng,Xi

doi:10.3892/or.2024.8816

The molecular mechanisms of chemotherapeutic resistance in tumors (Review)

Authors:
- Xin Weng
- Wei-Hong Zeng
- Li-Yuan Zhong
- Li-Hua Xie
- Wen-Jun Ge
- Zhen Lai
- Qin Qin
- Peng Liu
- De-Liang Cao
- Xi Zeng
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Affiliations: Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R China, Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410000, P.R. China, Department of Pathology, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Gastroenterology, The First Affiliated Hospital (People's Hospital of Hunan), Hunan Normal University, Changsha, Hunan 410005, P.R. China
Published online on: September 30, 2024 https://doi.org/10.3892/or.2024.8816
Article Number: 157

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Abstract

Chemotherapy remains a prevalent treatment for a wide range of tumors; however, the majority of patients undergoing conventional chemotherapy experience varying levels of chemoresistance, ultimately leading to suboptimal outcomes. The present article provided an in‑depth review of chemotherapy resistance in tumors, emphasizing the underlying factors contributing to this resistance in tumor cells. It also explored recent advancements in the identification of key molecules and molecular mechanisms within the primary chemoresistant pathways.