Treatment of cervical intraepithelial neoplasia (CIN) with interferon alpha-2a, CO2 laser (vaporization, cone) and 5-fluorouracil

  • Authors:
    • E Cardamakis
    • E Koumantakis
    • C Relakis
    • I Kotoulas
    • A Korantzis
    • H Mantouvalos
    • C Metalinos
    • E Stathopoulos
    • V Tzingounis
  • View Affiliations

  • Published online on: May 1, 1996     https://doi.org/10.3892/or.3.3.531
  • Pages: 531-534
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Abstract

This study was undertaken to assess the effect of CO2 laser (vaporization, conization), 5-FU topical application and interferon alpha-2a parenterally in the therapy of GIN. Three hundred and forty-seven (347) women with CIN were treated with CO2 laser (vaporization, conization), 5-FU topical application and interferon alpha-2a parenterally. The cure rates in the various treatment groups were analysed by the chi(2) test. The most effective treatment used for CIN I was the combination of CO2 laser vaporization plus 5-FU (p<0.05). The most effective treatment used for CIN II was the combination of CO2 laser vaporization plus 5-FU (p<0.001). The treatment modalities used for patients with CIN III achieved the same therapeutic results (p>0.1). The addition of interferon does not achieve better cure rates in patients with CIN.

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May 1996
Volume 3 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cardamakis E, Koumantakis E, Relakis C, Kotoulas I, Korantzis A, Mantouvalos H, Metalinos C, Stathopoulos E and Tzingounis V: Treatment of cervical intraepithelial neoplasia (CIN) with interferon alpha-2a, CO2 laser (vaporization, cone) and 5-fluorouracil. Oncol Rep 3: 531-534, 1996
APA
Cardamakis, E., Koumantakis, E., Relakis, C., Kotoulas, I., Korantzis, A., Mantouvalos, H. ... Tzingounis, V. (1996). Treatment of cervical intraepithelial neoplasia (CIN) with interferon alpha-2a, CO2 laser (vaporization, cone) and 5-fluorouracil. Oncology Reports, 3, 531-534. https://doi.org/10.3892/or.3.3.531
MLA
Cardamakis, E., Koumantakis, E., Relakis, C., Kotoulas, I., Korantzis, A., Mantouvalos, H., Metalinos, C., Stathopoulos, E., Tzingounis, V."Treatment of cervical intraepithelial neoplasia (CIN) with interferon alpha-2a, CO2 laser (vaporization, cone) and 5-fluorouracil". Oncology Reports 3.3 (1996): 531-534.
Chicago
Cardamakis, E., Koumantakis, E., Relakis, C., Kotoulas, I., Korantzis, A., Mantouvalos, H., Metalinos, C., Stathopoulos, E., Tzingounis, V."Treatment of cervical intraepithelial neoplasia (CIN) with interferon alpha-2a, CO2 laser (vaporization, cone) and 5-fluorouracil". Oncology Reports 3, no. 3 (1996): 531-534. https://doi.org/10.3892/or.3.3.531