Hydroxyurea as a modulator of multidrug resistance in resistant solid tumor

  • Authors:
    • V Leonardi
    • M Meli
    • S Palmeri
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/or.4.4.723
  • Pages: 723-727
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We enrolled 11 consecutive pre-treated resistant advanced cancer patients to receive hydroxyurea (HU) (as modulator of MDR) 10 mg/kg/day (d) p.o. d 1-14 in association with DXR (d 15) alone or in combination with VDS (d 15) or VP16 (d 15-17) in presence, respectively, of soft tissue sarcoma, breast carcinoma, lung and gastric carcinoma. We obtained a stabilization of disease (NC) in 62.5% of patients, with a mean duration of 6 months. The mean survival was 12.2+ months for NC and 6 months for progressive disease (PD). No severe or unexpected adverse events were reported over 34 cycles administered; the most frequently recorded side effects were haematological and gastrointestinal toxicity. It seems that at the dosage we used, HU is poorly active in overcoming MDR; further studies with larger number of patients and different dosage are needed.

Related Articles

Journal Cover

July 1997
Volume 4 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Leonardi V, Meli M and Palmeri S: Hydroxyurea as a modulator of multidrug resistance in resistant solid tumor. Oncol Rep 4: 723-727, 1997
APA
Leonardi, V., Meli, M., & Palmeri, S. (1997). Hydroxyurea as a modulator of multidrug resistance in resistant solid tumor. Oncology Reports, 4, 723-727. https://doi.org/10.3892/or.4.4.723
MLA
Leonardi, V., Meli, M., Palmeri, S."Hydroxyurea as a modulator of multidrug resistance in resistant solid tumor". Oncology Reports 4.4 (1997): 723-727.
Chicago
Leonardi, V., Meli, M., Palmeri, S."Hydroxyurea as a modulator of multidrug resistance in resistant solid tumor". Oncology Reports 4, no. 4 (1997): 723-727. https://doi.org/10.3892/or.4.4.723